| Rapid Prototyping a Double-layer Polyurethane-collagen Conduit and its Schwann Cell Compatibility | |
| Cui, Tongkui ; Wang, Xiaohong ; Yan, Yongnian ; Zhang, Renji | |
| 2010-10-12 ; 2010-10-12 | |
| 关键词 | rapid prototyping Schwann cell doubled layered poly (urethane-collagen) nerve conduits low-temperature deposition technology tissue engineering PERIPHERAL-NERVE REGENERATION BIOARTIFICIAL LIVERS GUIDE CONDUIT GRAFT Biotechnology & Applied Microbiology Materials Science, Biomaterials Polymer Science |
| 中文摘要 | A new double-layer conduit that combined an outer synthetic polyurethane (PU) layer and inner natural collagen layer was fabricated via a double-nozzle low-temperature deposition manufacturing (DLDM) technology. The outer PU layer provided a mechanically stable tunnel against scar tissue invasion in vivo, while the inner collagen layer promoted Schwann cell adhesion, migration, and proliferation. Microporous structures were found in both the layers. A tight connection between the double layers was achieved by adjusting the distance between the two deposit nozzles and adjusting other processing parameters. Schwann cells from rat sciatic nerves were cultured in the layered PU-collagen conduits for one week; a significant enhancement in their retention and viability was seen compared to those made of pure PU. The poly(urethane collagen) double layer conduit had better Schwann cell compatibility and so has a great potential use in clinical peripheral nerve repair. |
| 语种 | 英语 ; 英语 |
| 出版者 | SAGE PUBLICATIONS LTD ; LONDON ; 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/80525]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | Cui, Tongkui,Wang, Xiaohong,Yan, Yongnian,et al. Rapid Prototyping a Double-layer Polyurethane-collagen Conduit and its Schwann Cell Compatibility[J],2010, 2010. |
| APA | Cui, Tongkui,Wang, Xiaohong,Yan, Yongnian,&Zhang, Renji.(2010).Rapid Prototyping a Double-layer Polyurethane-collagen Conduit and its Schwann Cell Compatibility.. |
| MLA | Cui, Tongkui,et al."Rapid Prototyping a Double-layer Polyurethane-collagen Conduit and its Schwann Cell Compatibility".(2010). |
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