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	甲壳素纤维增强骨组织工程框架材料
	冯庆玲 ; 李晓明 ; FENG Qingling ; LI Xiaoming
	2010-07-15 ; 2010-07-15
会议名称	中国复合材料学术研讨会论文集 ; 中国复合材料学术研讨会 ; 中国天津 ; CNKI ; 中国复合材料学会
关键词	甲壳素纤维(CF) 增强 框架材料 骨组织工程 chitin Fibers (CF) reinforce scaffold bone tissue engineering R318.08
其他题名	The scaffold reinforced by chitin fibres for bone tissue engineering
中文摘要	制备了新颖的甲壳素纤维(CF)增强多孔胶原基骨组织工程框架材料,其成分为纳米羟基磷灰石/胶原/ 聚-L乳酸/甲壳素纤维(nHAC/PLLA/CF)。为了进一步增强支架材料,采用蛋白交联试剂N,N’-二环己基碳酰亚胺(DCC)交联CF和聚-L-乳酸(PLLA)。采用扫描电镜(SEM)观察了交联前后的框架材料,采用X-射线光电子能谱(XPS)表征了交联前后的CF,测试了框架材料的压缩强度和孔隙率。结果表明,与PLLA成功交联后的CF 能够使材料的压缩强度提高4-5倍;而在没有进行交联的情况下,CF仅能使材料的压缩强度提高2-2．5倍。交联后的材料与没有进行交联的材料相比,结构和孔隙分布更加均匀,而孔隙率没有明显的变化。所以,经过交联后的nHAC/PLLA/CF框架材料是一种很有前途的骨组织工程框架材料。; In this paper, a novel porous scaffold for bone tissue engineering was prepared with nano-hydroxyapa tite/collagen/Poly-L-lactic acid (PLLA) composite reinforced by chitin fibres (CF). To enhance the strength of the scaffolds further, PLLA was linked with CF by Dicyclohexylcarbodimide (DCC). The structures of the reinforced scaffold with and without linking were characterized by scanning electron microscopy (SEM). The chemical characteristics of the CF with and without linking were evaluated by X-ray photoelectron spectroscopy (XPS). The mechanical strength was measured by compressive tests. The results suggest that after linked with PLLA successfully, the CF can reinforce the scaffolds much more effectively. The linked scaffolds, with the compressive strength 4-5 times higher than that of the unreinforced scaffolds, have also more uniform structure and pore size than that of the scaffolds without linking. So the linked reinforced scaffold is a kind of potential appropriate scaffold for bone tissue engineering.; 国家自然科学基金(50272035)
语种	中文 ; 中文
内容类型	会议论文
源URL	[http://hdl.handle.net/123456789/66509]
专题	清华大学
推荐引用方式 GB/T 7714	冯庆玲,李晓明,FENG Qingling,等. 甲壳素纤维增强骨组织工程框架材料[C]. 见:中国复合材料学术研讨会论文集, 中国复合材料学术研讨会, 中国天津, CNKI, 中国复合材料学会.

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