| 氯仿萃取4-氨基吡啶过程 | |
| 郭玉良 ; 胡熙恩 ; GUO Yuliang ; HU Xien | |
| 2010-06-04 ; 2010-06-04 | |
| 关键词 | 4-氨基吡啶 氯仿 溶剂萃取 4-aminopyridine chloroform solvent extraction TQ251.3 |
| 其他题名 | Extraction of 4-aminopyridine with chloroform |
| 中文摘要 | 为提高4-氨基吡啶生产能力,采用溶剂萃取实验研究了该产品的分离回收过程及影响因素。结果表明,氯仿为工业过程适用的溶剂。4-氨基吡啶在氯仿和水相中的分配比随溶液pH值升高而增大,且为快速分子萃取过程。水相中硫酸钠和硫酸亚钛均对萃取过程有盐析效应,使分配比增大。该萃取过程热效应为5.632kJ/mol,受温度影响不大。确定了pH=11～12时4-氨基吡啶在有机相与水相中分配平衡关系。当有机相和水相间体积比为2时,5级错流萃取的回收率为96%以上,测定值与预测值吻合较好。当体积比为4时,8级逆流萃取4-氨基吡啶的回收率也可达96%以上。该研究结果为工业生产提供了基础数据。; The key factor affecting the solvent extraction processes and the recovery of 4-aminopyridine from the reaction solution were studied experimentally to improve the production capability. Chloroform was found to be the most suitable extractant for industrial applications compared with other solvents. The experimental results showed that the process was a fast molecular extraction and that the distribution ratio increased with increasing pH in the aqueous solution. Sodium sulfate and titanium (Ⅲ) sulfate in the aqueous solution had a salting-out effect which enhanced the distribution ratio. The extraction enthalpy was measured experimentally as 5.632 kJ/mol. The distribution equilibrium relation is given for 4-aminopyridine with chloroform in aqueous solution at pH=11～12. With a flow ratio of 2 and 5-stage cross-flow extractions, the experimental recoveries are in good agreement with the predicted values. The calculated results show that 8-stage counter-current extraction would have a 4-aminopyridine recovery ratio of 96% with a flow ratio of 4. |
| 语种 | 中文 ; 中文 |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/36106]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | 郭玉良,胡熙恩,GUO Yuliang,等. 氯仿萃取4-氨基吡啶过程[J],2010, 2010. |
| APA | 郭玉良,胡熙恩,GUO Yuliang,&HU Xien.(2010).氯仿萃取4-氨基吡啶过程.. |
| MLA | 郭玉良,et al."氯仿萃取4-氨基吡啶过程".(2010). |
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