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	Morphological measurement of localized temperature increase amplitudes in breast infrared thermograms and its clinical application
	Xianwu Tang ; Haishu Ding ; Yun-e Yuan ; Qing Wang
	2010-05-11 ; 2010-05-11
关键词	Practical Experimental/ biological organs biomedical optical imaging biothermics cancer infrared imaging medical image processing sensitivity analysis temperature distribution tumours/ morphological measurement breast infrared thermogram malignant tumor localized temperature vascular patterns thermographic detection breast cancer detection visual analysis surface temperature distribution carcinomatous possibility morphological signal processing receiver operating characteristic curve ROC curve Youden index maximization/ A8760F Optical and laser radiation (medical uses) A8770E Patient diagnostic methods and instrumentation A8716 Biothermics B7510J Optical and laser radiation (biomedical imaging/measurement) B6135 Optical, image and video signal processing C7330 Biology and medical computing C5260B Computer vision and image processing techniques
中文摘要	Malignant tumors will cause localized temperature increases (LTI) on breast surface which show as spot or vascular patterns in breast infrared thermograms. Thermographic detection of breast cancer now primarily depends on the visual analysis of these patterns by physicians, which is hard to provide objective and quantitative results. In this paper, we propose a new criterion of breast cancer detection and the method of its realization as follows: (1) surface temperature distribution of a healthy breast usually exhibits a gentle variation which is background. (2) Localized surface temperature of a carcinomatous breast will increase on the basis of the above background which is LTI. (3) The carcinomatous possibility is proportional to the LTI maximum (amplitude) of the suspicious focus region. (4) The LTI amplitude can be measured through morphological signal processing. According to the above conception, we obtained LTI amplitudes of 117 breast disease patients including 70 benign cases and 47 malignant cases. The optimal LTI amplitude threshold for breast cancer detection is determined as 1 degrees C from the ROC (receiver operating characteristic) curve based on the rule of Youden's index maximization. 44 cases were screened out from 47 breast cancer patients under this threshold. High sensitivity 93.6% and high NPV (negative predictive value) 91.2% demonstrate the value of this method on preliminary screening of breast cancer. High FPR (false-positive rate) 55.7% suggests that it is better to apply this method together with others. [All rights reserved Elsevier].
语种	英语 ; 英语
出版者	Elsevier Science B.V. ; Netherlands
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/27684]
专题	清华大学
推荐引用方式 GB/T 7714	Xianwu Tang,Haishu Ding,Yun-e Yuan,et al. Morphological measurement of localized temperature increase amplitudes in breast infrared thermograms and its clinical application[J],2010, 2010.
APA	Xianwu Tang,Haishu Ding,Yun-e Yuan,&Qing Wang.(2010).Morphological measurement of localized temperature increase amplitudes in breast infrared thermograms and its clinical application..
MLA	Xianwu Tang,et al."Morphological measurement of localized temperature increase amplitudes in breast infrared thermograms and its clinical application".(2010).

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