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	Statin, like aspirin, should be given as early as possible in patients with acute coronary syndrome
	Fang, CH ; Li, JJ ; Hui, RT
	2010-05-11 ; 2010-05-11
关键词	C-REACTIVE PROTEIN CARDIOVASCULAR-DISEASE UNSTABLE ANGINA LIPID PROFILE SIMVASTATIN RISK HYPERCHOLESTEROLEMIA INFLAMMATION ATHEROSCLEROSIS INTERLEUKIN-6 Medicine, Research & Experimental
中文摘要	It is estimated that about 1 million patients are hospitalized for acute coronary events each years in the United States. An acceptable theory is that the acute coronary syndrome is caused by rupture of the atherosclerotic plaque with superimposed thrombus, which is a complex process and involving a number of different stages. Previous studies indicated that inflammation is one of the most important features of vulnerable plaque, and occurs in most vulnerable plaque, comprised of monocytes, macrophages, and lymphocytes in both the cap and in the adventitia. This is supported by evidence that reduction in serum inflammatory marker levels, such as C-reactive protein, significantly decreased coronary events in patients with acute coronary syndrome. A large number of investigations have demonstrated that administration of statin could modify C-reactive protein concentrations with a concurrent fall in cardiovascular events. Our recent data indicated that reduction of inflammatory markers could be achieved within 24 h following a single dose of statin administration after admission in patients with coronary artery disease. Based on the available evidence and in light of the new understanding that statins have pleiotropic effects, especially as a potent anti-inflammatory agent, the statins, like aspirin, should be clinically given as early as possible in patients with acute coronary syndrome. (C) 2004 Elsevier Ltd. All rights reserved.
语种	英语 ; 英语
出版者	CHURCHILL LIVINGSTONE ; EDINBURGH ; JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/27620]
专题	清华大学
推荐引用方式 GB/T 7714	Fang, CH,Li, JJ,Hui, RT. Statin, like aspirin, should be given as early as possible in patients with acute coronary syndrome[J],2010, 2010.
APA	Fang, CH,Li, JJ,&Hui, RT.(2010).Statin, like aspirin, should be given as early as possible in patients with acute coronary syndrome..
MLA	Fang, CH,et al."Statin, like aspirin, should be given as early as possible in patients with acute coronary syndrome".(2010).

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