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	Smad3 mediates TGF-beta 1 induction of VEGF production in lung fibroblasts
	Kobayashi, T ; Liu, XD ; Wen, FQ ; Fang, QH ; Abe, S ; Wang, XQ ; Hashimoto, M ; Shen, L ; Kawasaki, S ; Kim, HJ ; Kohyama, T ; Rennard, SI
	2010-05-11 ; 2010-05-11
关键词	small interference RNA Smad2 Smad3 transforming growth factor-beta 1 vascular endothelial growth factor ENDOTHELIAL GROWTH-FACTOR TGF-BETA TARGETED DISRUPTION SIGNAL-TRANSDUCTION RNA INTERFERENCE LACKING CELLS Biochemistry & Molecular Biology Biophysics
中文摘要	Transforining growth factor-beta1 (TGF-beta1) is a key factor in a variety of physiological and pathological processes. Vascular endothelial growth factor (VEGF) is a key angiogenic factor. and vascular change is one of the features of airway remodeling. We examined the effect of TGF-beta1 on VEGF production by fibroblasts from mice lacking expression of Smad2 or Smad3 as well as human lung fibroblasts treated with or without Smad2 or Smad3 siRNA. TGF-beta1 stimulated VEGF production by fibroblasts from Smad2 deficient annuals and wildtype animals. In contrast, TGF-beta1 did not affect VEGF production by fibroblasts from Samd3 deficient mice. Similarly, TGF-beta1 failed to stimulate VEGF production by HFL-1 cells treated with Samd3 siRNA but significantly increased VEGF production by the cells treated with Smad2 siRNA. These result suggest that TGF-beta1 stimulation of VEGF production by fibroblasts is regulated by Smad3 but not by Smad2 signaling. (C) 2004 Elsevier Inc. All rights reserved.
语种	英语 ; 英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE ; SAN DIEGO ; 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/27615]
专题	清华大学
推荐引用方式 GB/T 7714	Kobayashi, T,Liu, XD,Wen, FQ,et al. Smad3 mediates TGF-beta 1 induction of VEGF production in lung fibroblasts[J],2010, 2010.
APA	Kobayashi, T.,Liu, XD.,Wen, FQ.,Fang, QH.,Abe, S.,...&Rennard, SI.(2010).Smad3 mediates TGF-beta 1 induction of VEGF production in lung fibroblasts..
MLA	Kobayashi, T,et al."Smad3 mediates TGF-beta 1 induction of VEGF production in lung fibroblasts".(2010).

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