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	Time course of inflammatory response after renal artery stenting in patients with atherosclerotic renal stenosis
	Li, JJ ; Fang, CH ; Jiang, H ; Huang, CX ; Hui, RT ; Chen, MZ
	2010-05-11 ; 2010-05-11
关键词	atherosclerotic renal artery stenosis percutaneous transluminal renal angioplasty stenting C-reactive protein interlukin-6 inflammation C-REACTIVE PROTEIN SEVERE UNSTABLE ANGINA AMYLOID-A-PROTEIN CORONARY ANGIOPLASTY HEART-DISEASE LIPID PROFILE RISK REPERFUSION SIMVASTATIN NEUTROPHILS Medical Laboratory Technology
中文摘要	Background: Inflammatory response has been demonstrated in patients with coronary artery disease after percutaneous coronary intervention (PCI). Such response following renal artery stenting has not yet been established, however, in patients with atherosclerotic renal artery stenosis. Methods: A total of 44 patients were enrolled in this study. Of them, 22 patients with atherosclerotic renal artery stenosis received renal angioplasty with stent (group A, mean age 51 +/- 8 years), and 22 patients with age- and gender-matched underwent renal angiography for diagnostic purpose as a control group (group B, age 50 +/- 8 years). The peripheral blood samples were taken immediately before the procedure, 1, 6 and 24 h after the procedure in both groups. The concentrations of C-reactive protein (CRP) and interleukin-6 (IL-6) were measured using ELISA. Results: The result showed that there was no difference in clinical characteristics and baseline levels of CRP and IL-6 between the groups. The IL-6 increased in the first hour (before: 5.8 +/- 3 pg/ml; 1 h: 8.6 +/-5 pg/ml, p<0.01), lasted at 6 h (12.2 +/- 8 pg/ml), returned to baseline at 24 h (5.4 +/- 3 pg/ml) in group A. The CRP did not changed at the first hour after stenting, but mean CRP increased from 0.30 +/- 0.09 to 0.37 +/- 0.15 mg/dl at 6 h (p<0.05), and peaked at 24 h (0.43 +/- 0.18 mg/dl, p<0.001 compared with baseline and control) after stenting in group A, while no such changes were observed in group B (p>0.05 at different time points compared with baseline and group B, respectively). Conclusions: The data indicated that renal artery stenting could trigger inflammatory response by evidence of increased plasma levels of CRP and IL-6. IL-6, however, was an early initiator of inflammatory cytokine, and CRP was a later marker of systemic inflammatory response to renal artery stenting. (C) 2004 Elsevier B.V. All rights reserved.
语种	英语 ; 英语
出版者	ELSEVIER SCIENCE BV ; AMSTERDAM ; PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/27604]
专题	清华大学
推荐引用方式 GB/T 7714	Li, JJ,Fang, CH,Jiang, H,et al. Time course of inflammatory response after renal artery stenting in patients with atherosclerotic renal stenosis[J],2010, 2010.
APA	Li, JJ,Fang, CH,Jiang, H,Huang, CX,Hui, RT,&Chen, MZ.(2010).Time course of inflammatory response after renal artery stenting in patients with atherosclerotic renal stenosis..
MLA	Li, JJ,et al."Time course of inflammatory response after renal artery stenting in patients with atherosclerotic renal stenosis".(2010).

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