| The antigenic tip GPGRAFY of the V3 loop on HIV-1 gp120: Genetic variability and subtypes | |
| Dong, XN ; Wu, Y ; Ying, H ; Chen, YH | |
| 2010-05-11 ; 2010-05-11 | |
| 关键词 | genetic variability subtype V3 GPGRAFY restricted mutation IMMUNODEFICIENCY-VIRUS TYPE-1 HUMAN MONOCLONAL-ANTIBODY NEUTRALIZATION SITE CRYSTAL-STRUCTURE EPITOPE GLYCOPROTEIN INFECTION COMPLEX TROPISM DOMAIN Immunology |
| 中文摘要 | V3 loop on HIV-1 gp120 is tightly correlated with syncytium formation, coreceptor usage, vir-us infectivity and antibody neutralization. The antigenic tip GPGRAFY with its flanking sequence has a conserved secondary structure, and is the target of neutralizing antibodies. We analyzed its genetic variability in 30096 M-group isolates and 269 O-group isolates. Subtype-related restricted mutations were observed, which could help to identify subtypes. (c) 2005 Elsevier B.V. All rights reserved. |
| 语种 | 英语 ; 英语 |
| 出版者 | ELSEVIER SCIENCE BV ; AMSTERDAM ; PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/27048]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | Dong, XN,Wu, Y,Ying, H,et al. The antigenic tip GPGRAFY of the V3 loop on HIV-1 gp120: Genetic variability and subtypes[J],2010, 2010. |
| APA | Dong, XN,Wu, Y,Ying, H,&Chen, YH.(2010).The antigenic tip GPGRAFY of the V3 loop on HIV-1 gp120: Genetic variability and subtypes.. |
| MLA | Dong, XN,et al."The antigenic tip GPGRAFY of the V3 loop on HIV-1 gp120: Genetic variability and subtypes".(2010). |
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