| Direct construction of a three-dimensional structure with cells and hydrogel | |
| Yan, YN ; Wang, XH ; Xiong, Z ; Liu, HX ; Liu, F ; Lin, F ; Wu, RD ; Zhang, RJ ; Lu, QP | |
| 2010-05-10 ; 2010-05-10 | |
| 关键词 | cell assembly rapid prototyping three-dimensional precursor implantable bioartificial liver hydrogel hepatocyte SCAFFOLDS DEPOSITION Biotechnology & Applied Microbiology Materials Science, Biomaterials Polymer Science |
| 中文摘要 | An organ manufacturing technique was developed that enables the formation of cell/extracellular matrix (ECM) complexes for in vitro or in vivo growth. In this study, a three-dimensional (3D) structure composed of hepatocytes and gelatin/alginate hydrogel was made using a cell assembler-I apparatus to thoroughly control cell assembling. Hepatocytes and ECM were constructed into 10 X 10 X 3 mm(3) structures according to a designed pattern. The embedded hepatocytes remained viable and performed biological functions in the construct for more than 12 days. This 3D structure has the potential to be used as a precursor for tissue or organ regeneration. This technology offers the potential for high-throughput production of artificial human tissues and organs. |
| 语种 | 英语 ; 英语 |
| 出版者 | SAGE PUBLICATIONS LTD ; LONDON ; 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/24030]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | Yan, YN,Wang, XH,Xiong, Z,et al. Direct construction of a three-dimensional structure with cells and hydrogel[J],2010, 2010. |
| APA | Yan, YN.,Wang, XH.,Xiong, Z.,Liu, HX.,Liu, F.,...&Lu, QP.(2010).Direct construction of a three-dimensional structure with cells and hydrogel.. |
| MLA | Yan, YN,et al."Direct construction of a three-dimensional structure with cells and hydrogel".(2010). |
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