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	Bone regeneration of critical calvarial defect in goat model by PLGA/TCP/rhBMP-2 scaffolds prepared by low-temperature rapid-prototyping technology
	Yu, D. ; Li, Q. ; Mu, X. ; Chang, T. ; Xiong, Z.
	2010-05-10 ; 2010-05-10 ; OCT
关键词	artificial bone cranium defect goat model IN-SITU OSTEOGENESIS MORPHOGENETIC PROTEIN-2 COLLAGEN IMPLANT DIFFERENTIATION DISTRACTION RHBMP-2 SYSTEM CORAL Dentistry, Oral Surgery & Medicine Surgery
中文摘要	Active artificial bone composed of poly lactide-co-glycolide (PLGA)/tricalcium phosphate (TCP) was prefabricated using low-temperature rapid-prototyping technology so that the process of osteogenesis could be observed in it. PLGA and TCP were the primary materials, they were molded at low temperature, then recombinant human bone morphogenetic protein-2 (rhBMP-2) was added to form an active artificial bone. Goats with standard cranial defects were randomly divided into experimental (implants with rhBMP-2 added) and control (implants without rhBMP-2) groups, and osteogenesis was observed and evaluated by imaging and biomechanical and histological examinations. The PLGA-TCP artificial bone scaffold (90% porosity) had large and small pores of approximately 360 mu m and 3-5 mu m diameter. Preliminary and complete repair of the cranial defect in the goats occurred 12 and 24 weeks after surgery, respectively. The three-point bending strength of the repaired defects attained that of the normal cranium. In conclusion, low-temperature rapid-prototyping technology can preserve the biological activity of this scaffold material. The scaffold has a good three-dimensional structure and it becomes an active artificial bone after loading with rhBMP-2 with a modest degradation rate and excellent osteogenesis in the goat.
语种	英语 ; 英语
出版者	CHURCHILL LIVINGSTONE ; EDINBURGH ; JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/23786]
专题	清华大学
推荐引用方式 GB/T 7714	Yu, D.,Li, Q.,Mu, X.,et al. Bone regeneration of critical calvarial defect in goat model by PLGA/TCP/rhBMP-2 scaffolds prepared by low-temperature rapid-prototyping technology[J],2010, 2010, OCT.
APA	Yu, D.,Li, Q.,Mu, X.,Chang, T.,&Xiong, Z..(2010).Bone regeneration of critical calvarial defect in goat model by PLGA/TCP/rhBMP-2 scaffolds prepared by low-temperature rapid-prototyping technology..
MLA	Yu, D.,et al."Bone regeneration of critical calvarial defect in goat model by PLGA/TCP/rhBMP-2 scaffolds prepared by low-temperature rapid-prototyping technology".(2010).

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