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	Genetic polymorphisms of CYP3A5 genes and concentration of the cyclosporine and tacrolimus
	Zhao, Y ; Song, M ; Guan, D ; Bi, S ; Meng, J ; Li, Q ; Wang, W
	2010-05-10 ; 2010-05-10
会议名称	TRANSPLANTATION PROCEEDINGS ; 20th International Congress of the Transplantion-Society ; Vienna, AUSTRIA ; Web of Science
关键词	TRANSPLANT PATIENTS P-GLYCOPROTEIN EXPRESSION IMMUNOSUPPRESSION ABSORPTION Immunology Surgery Transplantation
中文摘要	Objective. CYP3A is the major enzyme responsible for metabolism of the calcineurin inhibitors cyclosporine (CsA) and tacrolimus. Our objective was to determine the relationship between genetic polymorphisms of CYP3A5 with respect to interindividual variability in CsA and tacrolimus pharmacokinetics. Methods. Kidney transplant recipients receiving CsA (n = 137) or tacrolimus (n = 30) were genotyped for CYP3A5*3 and *6 by a PCR/RFLP method. The patients were grouped according to the CYP3A5 genotype. Dose-adjusted trough levels were correlated with the corresponding genotype. Results. At 3, 6, and 12 months, the tacrolimus dose-adjusted trough levels (dose-adjusted CO) showed a statistically significant difference between the group of CYP3A5 *3/*3 (n = 19) and the group of CYP3A5*1 allele carriers. The former was higher than the latter. The CsA dose-adjusted CO and the actual CO did not display a significant relation (P < .05) between the group of CYP3A5*3/*3 and the group of CYP3A5*1 allele carriers. Conclusion. Patients with the CYP3A5*3/*3 genotype require less tacrolimus to reach target concentrations compared to those with the CYP3A5*1 allele.
会议录出版者	ELSEVIER SCIENCE INC ; NEW YORK ; 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
语种	英语 ; 英语
内容类型	会议论文
源URL	[http://hdl.handle.net/123456789/20207]
专题	清华大学
推荐引用方式 GB/T 7714	Zhao, Y,Song, M,Guan, D,et al. Genetic polymorphisms of CYP3A5 genes and concentration of the cyclosporine and tacrolimus[C]. 见:TRANSPLANTATION PROCEEDINGS, 20th International Congress of the Transplantion-Society, Vienna, AUSTRIA, Web of Science.

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