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	Gelatin blending improves the performance of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)films for biomedical application
	Wang, YW ; Wu, Q ; Chen, GQ
	2010-05-10 ; 2010-05-10
会议名称	BIOMACROMOLECULES ; International Symposium on Biological Polyesters ; Beijing, PEOPLES R CHINA ; Web of Science
关键词	MICROBIAL POLYHYDROXYALKANOATES BONE-MARROW IN-VITRO DEGRADATION BIOCOMPATIBILITY PROLIFERATION SCAFFOLDS POLY(D,L-LACTIDE-CO-GLYCOLIDE) DIFFERENTIATION CHONDROCYTES Biochemistry & Molecular Biology Chemistry, Organic Polymer Science
中文摘要	To improve the performance of poly(3-hydroxybutyrate-co-3-ftydroxyhexanoate) (PHBHHx), gelatin was blended with PHBHHx at different ratios, With increasing gelatin content, the weight loss of gelatin/PHBHHx blend in simulated body fluid at 37 degrees C was accelerated. After 2 months, there was about 15% weight loss in PHBHHx blending with 30% gelatin. Scanning electron microscopy and X-ray diffraction results showed that gelatin blending increased the surface porosity and decreased the crystallinity, which may be responsible for the acceleration of the weight loss. Second harmonic generation results indicated that 10% gelatin blending had less disruption to PHBHHx spatial structure, resulting in better tensile mechanical properties. At the same time, increased surface porosity and decreased crystallinity caused by gelatin incorporation may be beneficial for cell growth compared with pure PHBHHx. All these indicated that gelatin incorporation may improve the performances of PHBHHx to meet the need of different situations during medical implantation.
会议录出版者	AMER CHEMICAL SOC ; WASHINGTON ; 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
语种	英语 ; 英语
内容类型	会议论文
源URL	[http://hdl.handle.net/123456789/20009]
专题	清华大学
推荐引用方式 GB/T 7714	Wang, YW,Wu, Q,Chen, GQ. Gelatin blending improves the performance of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)films for biomedical application[C]. 见:BIOMACROMOLECULES, International Symposium on Biological Polyesters, Beijing, PEOPLES R CHINA, Web of Science.

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