| Nonracemic Betti base as a new chiral auxiliary: Application to total syntheses of enantiopure (2S,6R)-dihydropinidine and (2S,6R)-isosolenopsins | |
| Wang, XY ; Dong, YM ; Sun, JW ; Xu, XN ; Li, R ; Hu, YF | |
| 2010-05-06 ; 2010-05-06 | |
| 关键词 | FIRE ANT VENOM ASYMMETRIC-SYNTHESIS ENANTIOSELECTIVE ADDITION ABSOLUTE-CONFIGURATION PIPERIDINE ALKALOIDS ARYL ALDEHYDES STEREOSELECTIVE SYNTHESIS DIETHYLZINC (-)-DIHYDROPINIDINE INDOLIZIDINE Chemistry, Organic |
| 中文摘要 | Total syntheses of enantiopure alkaloidal natural products (2S,6R)-dihydropinidine (as hydrochloride) and (2S,6R)isosolenopsins (as hydrochlorides) were achieved in four steps and in 80-82% total yields by using a synthetic strategy of the formation-cleavage of 1,3-oxazinane. (S)-Betti base was proved to be an excellent chiral auxiliary and a novel Pd/C catalyzed N-debenzylation straightforward to amine hydrochloride was developed in the presence of CH2Cl2. |
| 语种 | 英语 ; 英语 |
| 出版者 | AMER CHEMICAL SOC ; WASHINGTON ; 1155 16TH ST, NW, WASHINGTON, DC 20036 USA |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/13554]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | Wang, XY,Dong, YM,Sun, JW,et al. Nonracemic Betti base as a new chiral auxiliary: Application to total syntheses of enantiopure (2S,6R)-dihydropinidine and (2S,6R)-isosolenopsins[J],2010, 2010. |
| APA | Wang, XY,Dong, YM,Sun, JW,Xu, XN,Li, R,&Hu, YF.(2010).Nonracemic Betti base as a new chiral auxiliary: Application to total syntheses of enantiopure (2S,6R)-dihydropinidine and (2S,6R)-isosolenopsins.. |
| MLA | Wang, XY,et al."Nonracemic Betti base as a new chiral auxiliary: Application to total syntheses of enantiopure (2S,6R)-dihydropinidine and (2S,6R)-isosolenopsins".(2010). |
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