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	Concise preparation of N-alpha-Fmoc-N-epsilon-(Boc, methyl)-lysine and its application in the synthesis of site-specifically lysine monomethylated peptide
	Huang, Z.-P. ; Du, J.-T. ; Su, X.-Y. ; Chen, Y.-X. ; Zhao, Y.-F. ; Li, Y.-M.
	2010-05-06 ; 2010-05-06
关键词	lysine methylation benzylation monomethylated peptide synthesis ALPHA-AMINO-ACIDS HISTONE METHYLATION FACILE SYNTHESIS N-METHYLATION ESTERS H3 Biochemistry & Molecular Biology
中文摘要	A concise preparation of N-alpha- Fmoc- N-epsilon-( Boc, methyl)-lysine and its application in the synthesis of site-specifically lysine monomethylated peptide is described. Na- Fmoc- Ne-( Boc, methyl)-lysine is obtained, via consecutive reductive benzylation and reductive methylation in a one-pot reaction, followed by debenzylation through catalytic hydrogenolysis and Boc protection in another one-pot reaction. A peptide containing monomethylated lysine is successfully synthesized by incorporating N(alpha-)Fmoc- N-epsilon-(Boc, methyl)-lysine as a building block via solid-phase peptide synthesis.
语种	英语 ; 英语
出版者	SPRINGER ; NEW YORK ; 233 SPRING STREET, NEW YORK, NY 10013 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/13528]
专题	清华大学
推荐引用方式 GB/T 7714	Huang, Z.-P.,Du, J.-T.,Su, X.-Y.,et al. Concise preparation of N-alpha-Fmoc-N-epsilon-(Boc, methyl)-lysine and its application in the synthesis of site-specifically lysine monomethylated peptide[J],2010, 2010.
APA	Huang, Z.-P.,Du, J.-T.,Su, X.-Y.,Chen, Y.-X.,Zhao, Y.-F.,&Li, Y.-M..(2010).Concise preparation of N-alpha-Fmoc-N-epsilon-(Boc, methyl)-lysine and its application in the synthesis of site-specifically lysine monomethylated peptide..
MLA	Huang, Z.-P.,et al."Concise preparation of N-alpha-Fmoc-N-epsilon-(Boc, methyl)-lysine and its application in the synthesis of site-specifically lysine monomethylated peptide".(2010).

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