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	Neural tube defects and disturbed maternal folate- and homocysteine-mediated one-carbon metabolism
	Zhang, Hong-Yang ; Luo, Guo-An ; Liang, Qiong-Lin ; Wang, Yong ; Yang, Hui-Hua ; Wang, Yi-Ming ; Zheng, Xiao-Ying ; Song, Xin-Ming ; Chen, Gong ; Zhang, Ting ; Wu, Jian-Xin
	2010-05-06 ; 2010-05-06
关键词	neural tube defects potential fisk factors folate homocysteine one-carbon metabolism pathogenesis FOLIC-ACID FORTIFICATION HIGH PREVALENCE S-ADENOSYLHOMOCYSTEINE DNA HYPOMETHYLATION CHILDBEARING AGE HUMAN SERUM MAMMALIAN DEVELOPMENT MASS-SPECTROMETRY SHANXI PROVINCE WOMEN Neurosciences
中文摘要	Disturbances in maternal folate and homocysteine metabolism are associated with neural tube defects (NTDs). However, the role played by specific components in the one-carbon metabolic pathways leading to NTDs remains unclear. Here, we conducted a case-control study to investigate the relationship between the disturbed one-carbon metabolism and the risk of NTD-affected pregnancies. Major components were examined in population-based samples of women who had NTD-affected pregnancies (case subjects, n=46) or unaffected by any birth defects (control subjects, n=44). We used the newly developed high-performance liquid chromatography tandem mass spectrometry along with a routine chemiluminescent assay, to measure serum concentrations of 5-methyltetrahydrofolate (5-MeTHF), 5-formyltetrahydrofolate (5-FoTHF), folic acid, serine, histidine, homocysteine, cystathionine, methionine, S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), total folate and vitamin B12 in both groups adjusting for lifestyle and sociodemographic variables. We found significantly lower serum concentrations of 5-MeTHF (P<0.001), 5-FoTHF (P=0.004), total folate (P<0.001) and vitamin B12 (P=0.005) and remarkably higher concentrations of SAH (P=0.016) in cases than in controls. Therefore, these compounds could be identified as potential risk factors for NTD's early diagnosis. Further analysis of relevant genetic and epidemiologic investigations may provide more insights into the pathogenesis of NTDs and enhance current nutritional intervention strategies to reduce the risk of NTD-affected pregnancies. (C) 2008 Elsevier Inc. All rights reserved.
语种	英语 ; 英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE ; SAN DIEGO ; 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/12869]
专题	清华大学
推荐引用方式 GB/T 7714	Zhang, Hong-Yang,Luo, Guo-An,Liang, Qiong-Lin,et al. Neural tube defects and disturbed maternal folate- and homocysteine-mediated one-carbon metabolism[J],2010, 2010.
APA	Zhang, Hong-Yang.,Luo, Guo-An.,Liang, Qiong-Lin.,Wang, Yong.,Yang, Hui-Hua.,...&Wu, Jian-Xin.(2010).Neural tube defects and disturbed maternal folate- and homocysteine-mediated one-carbon metabolism..
MLA	Zhang, Hong-Yang,et al."Neural tube defects and disturbed maternal folate- and homocysteine-mediated one-carbon metabolism".(2010).

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