Injectable and thermally contractible hydroxypropyl methyl cellulose/Fe3O4 for magnetic hyperthermia ablation of tumors

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 高性能陶瓷和超微结构国家重点实验室 > 期刊论文

	Injectable and thermally contractible hydroxypropyl methyl cellulose/Fe3O4 for magnetic hyperthermia ablation of tumors
	Wang, Fengjuan 1,2,3; Yang, Yang 1,2,3; Ling, Yi 1,2,3; Liu, Jianxin 1,2,3; Cai, Xiaojun 5; Zhou, Xiaohan 1,2,3; Tang, Xiuzhen 1,2,3; Liang, Bing 1,2,3; Chen, Yini 4; Chen, Hangrong 5
刊名	BIOMATERIALS
	2017-06-01
卷号	128 页码:84-93
关键词	Thermally contractible Hydroxypropyl methyl cellulose Magnetic hyperthermia Tumor therapy
英文摘要	The development of efficient strategies for the magnetic hyperthermia ablation of tumors remains challenging. To overcome the significant safety limitations, we developed a thermally contractible, injectable and biodegradable material for the minimally invasive and highly efficient magnetic hyperthermia ablation of tumors. This material was composed of hydroxypropyl methyl cellulose (HPMC), polyvinyl alcohol (PVA) and Fe3O4. The thermal contractibility of HPMC/Fe3O4 was designed to avoid damaging the surrounding normal tissue upon heating, which was confirmed by visual inspection, ultrasound imaging and computed tomography (CT). The efficient injectability of HPMC/Fe3O4 was proven using a very small needle. The biosafety of HPMC/Fe3O4 was evaluated by MIT and biochemical assays as well as flow cytometry (FCM). All the aforementioned data demonstrated the safety of HPMC/Fe3O4. The results of in vitro and ex vivo experiments showed that the temperature and necrotic volume of excised bovine liver were positively correlated with the HPMC/Fe3O4 weight, iron content and heating duration. The in vivo experimental results showed that the tumors could be completely ablated using 0.06 ml of HPMC/60%Fe3O4 after 180 s of induction heating. We believe that this novel, safe and biodegradable material will promote the rapid bench -to -bed translation of magnetic hyperthermia technology, and it is also expected to bring a new concept for the biomaterial research field. (C) 2017 Elsevier Ltd. All rights reserved.
WOS标题词	Science & Technology ; Technology
类目[WOS]	Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]	Engineering ; Materials Science
关键词[WOS]	IN-VITRO ; NANOPARTICLES ; METHYLCELLULOSE ; BLENDS ; TRANSFORMATION ; IMPLANTS ; ALCOHOL) ; GELATION ; THERAPY ; DEXTRAN
收录类别	SCI
语种	英语
WOS记录号	WOS:000399512800008
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/23788]
专题	上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文
作者单位	1.Chongqing Med Univ, Affiliated Hosp 2, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China 2.Chongqing Med Univ, Affiliated Hosp 2, State Key Lab Ultrasound Engn Med Cofounded Chong, Chongqing 400010, Peoples R China 3.Chongqing Med Univ, Affiliated Hosp 2, Minist Sci & Technol, Chongqing 400010, Peoples R China 4.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai 200233, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 6.Chongqing Univ Sci & Technol, Ctr Mat Anal & Testing, Chongqing 400010, Peoples R China
推荐引用方式 GB/T 7714	Wang, Fengjuan,Yang, Yang,Ling, Yi,et al. Injectable and thermally contractible hydroxypropyl methyl cellulose/Fe3O4 for magnetic hyperthermia ablation of tumors[J]. BIOMATERIALS,2017,128:84-93.
APA	Wang, Fengjuan.,Yang, Yang.,Ling, Yi.,Liu, Jianxin.,Cai, Xiaojun.,...&Zheng, Yuanyi.(2017).Injectable and thermally contractible hydroxypropyl methyl cellulose/Fe3O4 for magnetic hyperthermia ablation of tumors.BIOMATERIALS,128,84-93.
MLA	Wang, Fengjuan,et al."Injectable and thermally contractible hydroxypropyl methyl cellulose/Fe3O4 for magnetic hyperthermia ablation of tumors".BIOMATERIALS 128(2017):84-93.