Identification of residues important for the activity of aldehyde-deformylating oxygenase through investigation into the structure-activity relationship

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	Identification of residues important for the activity of aldehyde-deformylating oxygenase through investigation into the structure-activity relationship
	Wang, Qing 1,2; Bao, Luyao 1,2; Jia, Chenjun 2,3; Li, Mei 3; Li, Jian-Jun 1,4; Lu, Xuefeng 1
刊名	BMC BIOTECHNOLOGY
	2017-03-16
卷号	17
关键词	Aldehyde-deformylating oxygenase Site-directed mutagenesis Structure-activity relationship Fatty alk(a/e) ne Synechococcus elongatus PCC7942 Synechocystis sp PCC6803
ISSN号	1472-6750
英文摘要	Background: Aldehyde-deformylating oxygenase (ADO) is a key enzyme involved in the biosynthetic pathway of fatty alk(a/e)nes in cyanobacteria. However, cADO (cyanobacterial ADO) showed extreme low activity with the k(cat) value below 1 min(-1), which would limit its application in biofuel production. To identify the activity related key residues of cADO is urgently required.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biotechnology & Applied Microbiology
研究领域[WOS]	Biotechnology & Applied Microbiology
关键词[WOS]	CYANOBACTERIAL ALDEHYDE ; FATTY ALDEHYDES ; DECARBONYLASE ; CONVERSION ; ALKANES ; INSIGHTS ; ENZYMES ; FORMATE
收录类别	SCI
语种	英语
WOS记录号	WOS:000396668000001
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/22108]
专题	过程工程研究所_生化工程国家重点实验室
作者单位	1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Key Lab Biofuels, Shandong Prov Key Lab Energy Genet, Qingdao 266101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Wang, Qing,Bao, Luyao,Jia, Chenjun,et al. Identification of residues important for the activity of aldehyde-deformylating oxygenase through investigation into the structure-activity relationship[J]. BMC BIOTECHNOLOGY,2017,17.
APA	Wang, Qing,Bao, Luyao,Jia, Chenjun,Li, Mei,Li, Jian-Jun,&Lu, Xuefeng.(2017).Identification of residues important for the activity of aldehyde-deformylating oxygenase through investigation into the structure-activity relationship.BMC BIOTECHNOLOGY,17.
MLA	Wang, Qing,et al."Identification of residues important for the activity of aldehyde-deformylating oxygenase through investigation into the structure-activity relationship".BMC BIOTECHNOLOGY 17(2017).