The role of conformational flexibility in Baeyer-Villiger monooxygenase catalysis and structure

	The role of conformational flexibility in Baeyer-Villiger monooxygenase catalysis and structure
	Yachnin, Brahm J.1,6; Lau, Peter C. K.3,4,5,7; Berghuis, Albert M.1,2,6
刊名	BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
	2016-12-01
卷号	1864 期号:12 页码:1641-1648
关键词	Baeyer-Villiger monooxygenase Small-angle X-ray scattering (SAXS) Isothermal titration calorimetry (ITC) Protein flexibility Enzyme mechanism Enzyme catalysis
英文摘要	Background: The Baeyer-Villiger monooxygenases (BMVOs) are a group of microbial enzymes that have garnered interest as industrial biocatalysts. While great strides have been made in recent years to understand the mechanism of these enzymes from a structural perspective, our understanding remains incomplete. In particular, the role of a twenty residue loop (residues 487-504), which we refer to as the "Control Loop," that is observed in either an ordered or disordered state in various crystal structures remains unclear.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	X-RAY-SCATTERING ; CYCLOHEXANONE MONOOXYGENASE ; ACINETOBACTER NCIB-9871 ; CRYSTAL-STRUCTURE ; OXYGENASE ; PROTEINS
收录类别	SCI
语种	英语
WOS记录号	WOS:000386861100002
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/2297]
专题	天津工业生物技术研究所_酶工程实验室马延和 _期刊论文
作者单位	1.McGill Univ, Dept Biochem, 3649 Promenade Sir William Oster,Bellini Pavil, Montreal, PQ H3G 0B1, Canada 2.McGill Univ, Dept Microbiol & Immunol, 3649 Promenade Sir William Oster,Bellini Pavil, Montreal, PQ H3G 0B1, Canada 3.McGill Univ, Dept Microbiol & Immunol, 3775 Univ St, Montreal, PQ H3A 2B4, Canada 4.McGill Univ, Dept Chem, 3775 Univ St, Montreal, PQ H3A 2B4, Canada 5.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Natl Engn Lab Ind Enzymes, 32 Xi Qi Dao, Tianjin 300308, Tianjin, Peoples R China 6.PROTEO, Grp Rech GRASP, Montreal, PQ, Canada 7.FQRNT Ctr Green Chem & Catalysis, Montreal, PQ, Canada
推荐引用方式 GB/T 7714	Yachnin, Brahm J.,Lau, Peter C. K.,Berghuis, Albert M.. The role of conformational flexibility in Baeyer-Villiger monooxygenase catalysis and structure[J]. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS,2016,1864(12):1641-1648.
APA	Yachnin, Brahm J.,Lau, Peter C. K.,&Berghuis, Albert M..(2016).The role of conformational flexibility in Baeyer-Villiger monooxygenase catalysis and structure.BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS,1864(12),1641-1648.
MLA	Yachnin, Brahm J.,et al."The role of conformational flexibility in Baeyer-Villiger monooxygenase catalysis and structure".BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1864.12(2016):1641-1648.