Near-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn2+ Detection and Selective On-Demand Photodynamic Therapy

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 高性能陶瓷和超微结构国家重点实验室 > 期刊论文

	Near-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn2+ Detection and Selective On-Demand Photodynamic Therapy
	Hu, Ping 1,2; Wang, Rui 1; Zhou, Lei 1; Chen, Lei 1; Wu, Qingsheng 3; Han, Ming-Yong 4; El-Toni, Ahmed Mohamed 5; Zhao, Dongyuan 1; Zhang, Fan 1
刊名	ANALYTICAL CHEMISTRY
	2017-03-21
卷号	89 期号:6 页码:3492-3500
英文摘要	As a light-activated noninvasive cancer treatment paradigm, photodynamic therapy (PDT) has attracted extensive attention because of its high treatment efficacy and low side effects. Especially, spatiotemporal control of singlet oxygen (O-1(2)) release is highly desirable for realizing on-demand PDT, which, however, still remains a huge challenge. To address this issue, a novel switchable near-infrared (NIR)-responsive upconversion nanoprobe has been designed and successfully applied for controlled PDT that can be optically activated by tumor associated disruption of labile Zn2+ (denoted as Zn2+ hereafter) homeostasis stimuli. Upon NIR irradiation, this theranostic probe can not only quantitatively detect the intracellular endogenous Zn2+ in situ but also selectively generate a great deal of cytotoxic reactive oxygen species (ROS) for efficiently killing breast cancer cells under the activation of excessive endogenous Zn2+, so as to maximally avoid adverse damage to normal cells. This study aims to propose a new tumor-specific PDT paradigm and, more importantly, provide a new avenue of thought for efficient cancer theranostics based on our designed highly sensitive upconversion nanoprobes.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Analytical
研究领域[WOS]	Chemistry
关键词[WOS]	SINGLET OXYGEN GENERATION ; OPTICAL-PROPERTIES ; PROSTATE-CANCER ; PHOTOSENSITIZER ; NANOPARTICLES ; ZINC ; LIGHT ; NANOCRYSTALS ; STRATEGY ; LAYER
收录类别	SCI
语种	英语
WOS记录号	WOS:000397478300035
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/23729]
专题	上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文
作者单位	1.Fudan Univ, State Key Lab Mol Engn Polymers, Collaborat Innovat Ctr Chem Energy Mat, Dept Chem, Shanghai 200433, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 3.Tongji Univ, Dept Chem, Shanghai 200092, Peoples R China 4.Inst Mat Res & Engn, 2 Fusionopolis Way, Singapore 138634, Singapore 5.King Saud Univ, King Abdullah Inst Nanotechnol, Riyadh 11451, Saudi Arabia
推荐引用方式 GB/T 7714	Hu, Ping,Wang, Rui,Zhou, Lei,et al. Near-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn2+ Detection and Selective On-Demand Photodynamic Therapy[J]. ANALYTICAL CHEMISTRY,2017,89(6):3492-3500.
APA	Hu, Ping.,Wang, Rui.,Zhou, Lei.,Chen, Lei.,Wu, Qingsheng.,...&Zhang, Fan.(2017).Near-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn2+ Detection and Selective On-Demand Photodynamic Therapy.ANALYTICAL CHEMISTRY,89(6),3492-3500.
MLA	Hu, Ping,et al."Near-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn2+ Detection and Selective On-Demand Photodynamic Therapy".ANALYTICAL CHEMISTRY 89.6(2017):3492-3500.