Treatment of steroid-induced osteonecrosis of the femoral head using porous Se@SiO2 nanocomposites to suppress reactive oxygen species

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 高性能陶瓷和超微结构国家重点实验室 > 期刊论文

	Treatment of steroid-induced osteonecrosis of the femoral head using porous Se@SiO2 nanocomposites to suppress reactive oxygen species
	Deng, Guoying 1; Niu, Kerun 2; Zhou, Feng 2; Li, Buxiao 1; Kang, Yingjie 3; Liu, Xijian 4; Hu, Junqing 5; Li, Bo 6; Wang, Qiugen 1; Yi, Chengqing 7
刊名	SCIENTIFIC REPORTS
	2017-03-03
卷号	7
英文摘要	Reducing oxidative stress (ROS) have been demonstrated effective for steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH). Selenium (Se) plays an important role in suppressing oxidative stress and has huge potential in ONFH treatments. However the Se has a narrow margin between beneficial and toxic effects which make it hard for therapy use in vivo. In order to make the deficiency up, a control release of Se (Se@SiO2) were realized by nanotechnology modification. Porous Se@SiO2 nanocomposites have favorable biocompatibility and can reduced the ROS damage effectively. In vitro, the cck-8 analysis, terminal dexynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) stain and flow cytometry analysis showed rare negative influence by porous Se@SiO2 nanocomposites but significantly protective effect against H2O2 by reducing ROS level (detected by DCFH-DA). In vivo, the biosafety of porous Se@SiO2 nanocomposites were confirmed by the serum biochemistry, the ROS level in serum were significantly reduced and the curative effect were confirmed by Micro CT scan, serum Elisa assay inflammatory factors), Western blotting (quantitative measurement of ONFH) and HE staining. It is expected that the porous Se@SiO2 nanocomposites may prevent steroid-induced ONFH by reducing oxidative stress.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	ENDOPLASMIC-RETICULUM STRESS ; OXIDATIVE-STRESS ; SELENIUM NANOPARTICLES ; ELEMENTAL SELENIUM ; AVASCULAR NECROSIS ; NONTRAUMATIC OSTEONECROSIS ; RAT MODEL ; IN-VITRO ; NANO-SE ; TOXICITY
收录类别	SCI
语种	英语
WOS记录号	WOS:000396171500001
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/23669]
专题	上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文
作者单位	1.Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Sch Med, Trauma Ctr, 650 Xin Songjiang Rd, Shanghai 201620, Peoples R China 2.Nanjing Med Univ, Shanghai Gen Hosp, Shanghai Bone Tumor Inst, Dept Orthoped, Shanghai 200080, Peoples R China 3.Shanghai Univ Tradit Chinese Medicine, Shuguang Hosp, Dept Radiol, 528 Zhangheng Rd, Shanghai 201203, Peoples R China 4.Shanghai Univ Engn Sci, Coll Chem & Chem Engn, Shanghai 201620, Peoples R China 5.Donghua Univ, Coll Mat Sci & Engn, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China 7.Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Sch Med, Shanghai Bone Tumor Inst,Dept Orthoped, 100 Haining Rd, Shanghai 200080, Peoples R China
推荐引用方式 GB/T 7714	Deng, Guoying,Niu, Kerun,Zhou, Feng,et al. Treatment of steroid-induced osteonecrosis of the femoral head using porous Se@SiO2 nanocomposites to suppress reactive oxygen species[J]. SCIENTIFIC REPORTS,2017,7.
APA	Deng, Guoying.,Niu, Kerun.,Zhou, Feng.,Li, Buxiao.,Kang, Yingjie.,...&Wang, Qian.(2017).Treatment of steroid-induced osteonecrosis of the femoral head using porous Se@SiO2 nanocomposites to suppress reactive oxygen species.SCIENTIFIC REPORTS,7.
MLA	Deng, Guoying,et al."Treatment of steroid-induced osteonecrosis of the femoral head using porous Se@SiO2 nanocomposites to suppress reactive oxygen species".SCIENTIFIC REPORTS 7(2017).