Effects of hypoxia in the gills of the Manila clam Ruditapes philippinarum using NMR-based metabolomics

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室

	Effects of hypoxia in the gills of the Manila clam Ruditapes philippinarum using NMR-based metabolomics
	Zhang, Ying ; Wu, Huifeng; Wei, Lei ; Xie, Zeping ; Guan, Bo
刊名	MARINE POLLUTION BULLETIN
	2017-01-15
卷号	114 期号:1 页码:84-89
关键词	Metabolic profile Hypoxia Ruditapes philippinarum Proton nuclear magnetic resonance Metabolomics
ISSN号	0025-326X
通讯作者	Zhang, Y (reprint author), Binzhou Med Univ, Sch Basic Med Sci, 346,Guanhai Rd, Yantai 264003, Peoples R China. zhangying@bzmc.edu.cn
产权排序	[Zhang, Ying; Xie, Zeping] Binzhou Med Univ, Sch Basic Med Sci, 346,Guanhai Rd, Yantai 264003, Peoples R China; [Wu, Huifeng; Wei, Lei; Guan, Bo] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
英文摘要	Coastal hypoxia affects the survival, behavior, and reproduction of individual local marine organisms, and the abundance, biomass, and biodiversity of coastal ecosystems. In this study, we investigated the chronic effects of hypoxia on the metabolomics in the gills of Ruditapes (R.) philippinarum. The results indicated significant alterations in the metabolite profiles in the gills of the hypoxia-treated clams, in comparison with those maintained under normoxia. The levels of betaine, taurine, glycine, isoleucine, and alanine were significantly reduced, suggesting a disturbance of osmotic balance associated with hypoxia. Meanwhile, metabolites involved in energy metabolism, such as alanine and succinate, were also affected. Dramatic histopathological changes were observed in the gills and hepatopancreases of R. philippinarum grown in hypoxic waters, demonstrating tissue damages apparently caused by long-term exposure to hypoxia. Our findings suggest that hypoxia significantly affects the physiology of R. philippinarum, even at a sub-lethal level, and impedes health of the clams. (C) 2016 Elsevier Ltd. All rights reserved.
研究领域[WOS]	Environmental Sciences & Ecology ; Marine & Freshwater Biology
关键词[WOS]	VIBRIO-HARVEYI CHALLENGE ; MYTILUS-GALLOPROVINCIALIS ; DIFFERENTIAL RESPONSES ; TAPES-PHILIPPINARUM ; OXYGEN LEVELS ; 2 PEDIGREES ; DECUSSATUS ; ZOOPLANKTON ; ADAPTATIONS ; BIOMARKERS
收录类别	SCI
语种	英语
WOS记录号	WOS:000392768900023
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/21934]
专题	烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
作者单位	1.Binzhou Med Univ, Sch Basic Med Sci, 346,Guanhai Rd, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ying,Wu, Huifeng,Wei, Lei,et al. Effects of hypoxia in the gills of the Manila clam Ruditapes philippinarum using NMR-based metabolomics[J]. MARINE POLLUTION BULLETIN,2017,114(1):84-89.
APA	Zhang, Ying,Wu, Huifeng,Wei, Lei,Xie, Zeping,&Guan, Bo.(2017).Effects of hypoxia in the gills of the Manila clam Ruditapes philippinarum using NMR-based metabolomics.MARINE POLLUTION BULLETIN,114(1),84-89.
MLA	Zhang, Ying,et al."Effects of hypoxia in the gills of the Manila clam Ruditapes philippinarum using NMR-based metabolomics".MARINE POLLUTION BULLETIN 114.1(2017):84-89.