miR-217 inhibits triple-negative breast cancer cell growth, migration, and invasion through targeting KLF5

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室

	miR-217 inhibits triple-negative breast cancer cell growth, migration, and invasion through targeting KLF5
	Zhou WH 1,2,3; Song FF 3,4; Liu CC 2; Peng Y 2; Mao SQ 5; Feng J[]1,2; Chen CS[]3; Wu QJ 3,4; Liu R 3; Wang LL 2
刊名	Plos One
	2017
卷号	12 期号:4 页码:e0176395
通讯作者	chenc@mail.kiz.ac.cn ; engjing8801530@163.com
英文摘要	Triple negative breast cancer (TNBC) is one of the most aggressive breast cancers without effective targeted therapies. Numerous studies have implied that KLF5 plays an important roles in TNBC. How is KLF5 regulated by microRNAs has not been well studied. Here, we demonstrated that miR-217 down-regulates the expression of KLF5 and KLF5's downstream target gene FGF-BP and Cyclin D1 in TNBC cell lines HCC1806 and HCC1937. Consequently, miR-217 suppresses TNBC cell growth, migration, and invasion. MiR-217 suppresses TNBC, at least partially, through down-regulating the KLF5 expression. These results suggest that the miR-217-KLF5 axis might serve as a potential target for treatment of TNBC.
收录类别	SCI
资助信息	This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences(XDA12010303 to Chen,C), the National Key Basic Research Program of China (2013CB910900 to Chen,C),National Nature Science Foundation of China(81325016and U1602221 to Chen,Cand81672624 to Feng,J), Shanghai health systemout standingac ademic leader training program(XBR2013114toFeng,J), Yunnan Applied Basic Research Key Projects (2015FA027 toLiu,R),Shanghai Municipal CommissionofHealthandFamilyPlanning (20164Y0274toLiu,C)and Shanghai Fengxian District Health and Family Planning Commission Project(20131414toPeng,Y).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/11071]
专题	昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_肿瘤生物学
作者单位	1.Third Clinical College, Southern Medical University, Guangdong Province, Guangzhou, China 2.Departmentof Laboratory Medicine & Central Laboratory, Southern Medical University Affiliated Fengxian Hospital, Shanghai, China 3.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Kunming Institute of Zoology, Chinese Academy of Sciences, Yunnan Province, Kunming, China 4.Department of Laboratory Medicine & Central Laboratory, Jinzhou Medical University Affiliated Fengxian Hospital, Shanghai, China 5.Hubei University of Medicine Affiliated Taihe Hospital, Hubei Province, Shiyan, China
推荐引用方式 GB/T 7714	Zhou WH,Song FF,Liu CC,et al. miR-217 inhibits triple-negative breast cancer cell growth, migration, and invasion through targeting KLF5[J]. Plos One,2017,12(4):e0176395.
APA	Zhou WH.,Song FF.,Liu CC.,Peng Y.,Mao SQ.,...&Wang LL.(2017).miR-217 inhibits triple-negative breast cancer cell growth, migration, and invasion through targeting KLF5.Plos One,12(4),e0176395.
MLA	Zhou WH,et al."miR-217 inhibits triple-negative breast cancer cell growth, migration, and invasion through targeting KLF5".Plos One 12.4(2017):e0176395.