Neurons Differentiated from Transplanted Stem Cells Respond Functionally to Acoustic Stimuli in the Awake Monkey Brain

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	Neurons Differentiated from Transplanted Stem Cells Respond Functionally to Acoustic Stimuli in the Awake Monkey Brain
	Wei JK 1,6; Wang WC 1,6; Rizak J 1; Xu LQ 3; Liu L 3; Pan MK 1; Li JL 1; Yao YG 1,2; Zhai RW 1,6; Xu L 1,2
刊名	Cell Reports
	2016
卷号	16 期号:4 页码:1016–1025
通讯作者	xthu@mail.kiz.ac.cn ; wangzb@mail.kiz.ac.cn
中文摘要
英文摘要	Here, we examine whether neurons differentiated from transplanted stem cells can integrate into the host neural network and function in awake animals, a goal of transplanted stem cell therapy in the brain. We have developed a technique in which a small "hole" is created in the inferior colliculus (IC) of rhesus monkeys, then stem cells are transplanted in situ to allow for investigation of their integration into the auditory neural network. We found that some transplanted cells differentiated into mature neurons and formed synaptic input/output connections with the host neurons. In addition, c-Fos expression increased significantly in the cells after acousticstimulation, and multichannel recordings indicated IC specific tuning activities in response to auditory stimulation. These results suggest that the transplanted cells have the potential to functionally integrate into the host neural network.
收录类别	SCI
资助信息	This research was supported by the National Program for Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020005), the Key Research Program of the Chinese Academy of Sciences, the Selected Frontier Scientific Significant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 31271167, 81271495, and 81460352), the Yunnan Provincial Project to Attract One-hun- dred Exceptional Talents From Overseas, and the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/11250]
专题	昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_认知障碍病理学昆明动物研究所_神经系统编码昆明动物研究所_学习记忆的分子神经机制昆明动物研究所_重大疾病机理的遗传学昆明动物研究所_表观遗传与神经退行性疾病昆明动物研究所_中国科学院昆明灵长类研究中心
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 2.CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China 3.Medical Imaging Department, Kunming General Hospital of PLA, Kunming, Yunnan 650032, China 4.Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 5.Department of Rehabilitation Medicine, Fourth Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650021, China 6.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, 650204, China
推荐引用方式 GB/T 7714	Wei JK,Wang WC,Rizak J,et al. Neurons Differentiated from Transplanted Stem Cells Respond Functionally to Acoustic Stimuli in the Awake Monkey Brain[J]. Cell Reports,2016,16(4):1016–1025.
APA	Wei JK.,Wang WC.,Rizak J.,Xu LQ.,Liu L.,...&Yang SC.(2016).Neurons Differentiated from Transplanted Stem Cells Respond Functionally to Acoustic Stimuli in the Awake Monkey Brain.Cell Reports,16(4),1016–1025.
MLA	Wei JK,et al."Neurons Differentiated from Transplanted Stem Cells Respond Functionally to Acoustic Stimuli in the Awake Monkey Brain".Cell Reports 16.4(2016):1016–1025.