Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair
	Wu, ZY; Zheng, K; Zhang, J; Tang, TT; Guo, H; Boccaccini, AR; Wei, J
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2016
卷号	4 期号:48 页码:7974-7988
ISSN号	2050-750X
通讯作者	Wei, J (reprint author), East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China. ; Boccaccini, AR (reprint author), Univ Erlangen Nurnberg, Inst Biomat, Dept Mat Sci & Engn, Cauerstr 6, D-91058 Erlangen, Germany.
英文摘要	Bioactive scaffolds of magnesium silicate (m-MS)/poly(butylene succinate) (PBSu) composites were fabricated by a solvent casting particulate leaching method for bone regeneration. The scaffolds had a hierarchical porous structure with interconnected macropores (300-500 mu m), micropores (1-10 mu m) and mesopores (similar to 5 nm). In addition, the composite scaffolds were degradable in Tris-HCl solution and formed apatite on their surfaces in simulated body fluid, indicating good degradability and bioactivity in vitro. Compared with PBSu scaffolds, the composite scaffolds improved the in vitro attachment, proliferation and osteogenic differentiation of MC3T3-E1 cells, revealing good cytocompatibility. Furthermore, the model of rabbit femur cavity defects was used to evaluate the in vivo osteogenesis of the composite scaffolds. The results of synchrotron radiation-based mCT (SRmCT) imaging, histological analysis and immunohistochemistry showed that the composite scaffolds were gradually degraded and replaced by new bone, and the scaffolds with 40 wt% m-MS (C40) almost completely disappeared after 12 weeks of implantation, indicating that the scaffolds containing m-MS enhanced new bone formation. The results demonstrated that the bioactive m-MS/PBSu composite scaffolds with good biocompatibility, degradability, bioactivity and osteogenesis are promising biomaterials for bone repair.
收录类别	SCI
语种	英语
WOS记录号	WOS:000391778200021
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/26492]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Wu, ZY,Zheng, K,Zhang, J,et al. Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair[J]. JOURNAL OF MATERIALS CHEMISTRY B,2016,4(48):7974-7988.
APA	Wu, ZY.,Zheng, K.,Zhang, J.,Tang, TT.,Guo, H.,...&Wei, J.(2016).Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair.JOURNAL OF MATERIALS CHEMISTRY B,4(48),7974-7988.
MLA	Wu, ZY,et al."Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair".JOURNAL OF MATERIALS CHEMISTRY B 4.48(2016):7974-7988.