Plasma sprayed cerium oxide coating inhibits H2O2-induced oxidative stress and supports cell viability

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 特种无机涂层重点实验室 > 期刊论文

	Plasma sprayed cerium oxide coating inhibits H2O2-induced oxidative stress and supports cell viability
	Li, Kai; Xie, Youtao; You, Mingyu; Huang, Liping; Zheng, Xuebin
刊名	JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
	2016-06-01
卷号	27 期号:6
英文摘要	Oxidative stress is a risk factor in the pathogenesis of osteoporosis, and plays a major role in bone regeneration of osteoporotic patients. Cerium oxide (CeO2) ceramics have the unique ability to protect various types of cells from oxidative damage, making them attractive for biomedical applications. In this study, we developed a plasma sprayed CeO2 coating with a hierarchical topography where ceria nanoparticles were superimposed in the micro-rough coating surface. The protective effects of the CeO2 coating on the response of osteoblasts to H2O2-induced oxidative stress have been demonstrated in terms of cell viability, apoptosis and differentiation. The CeO2 coating reversed the reduced superoxide dismutase activity, decreased reactive oxygen species production and suppressed malondialdehyde formation in H2O2-treated osteoblasts. It indicated that the CeO2 coating can preserve the intracellular antioxidant defense system. The cyto-compatibility of the CeO2 coating was further assessed in vitro by cell viability assay and scanning electron microscopy analysis. Taken together, the CeO2 coating could provide an opportunity to be utilized as a potential candidate for bone regeneration under oxidative stress.
WOS标题词	Science & Technology ; Technology
类目[WOS]	Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]	Engineering ; Materials Science
关键词[WOS]	HYDROGEN-PEROXIDE ; ALKALINE-PHOSPHATASE ; VALENCE STATES ; IN-VITRO ; NANOPARTICLES ; ANTIOXIDANT ; NANOCERIA ; OSSEOINTEGRATION ; PROLIFERATION ; OSTEOPOROSIS
收录类别	SCI
语种	英语
WOS记录号	WOS:000377373200001
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/22996]
专题	上海硅酸盐研究所_特种无机涂层重点实验室_期刊论文
作者单位	Chinese Acad Sci, Shanghai Inst Ceram, Key Lab Inorgan Coating Mat, 1295 Dingxi Rd, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	Li, Kai,Xie, Youtao,You, Mingyu,et al. Plasma sprayed cerium oxide coating inhibits H2O2-induced oxidative stress and supports cell viability[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2016,27(6).
APA	Li, Kai,Xie, Youtao,You, Mingyu,Huang, Liping,&Zheng, Xuebin.(2016).Plasma sprayed cerium oxide coating inhibits H2O2-induced oxidative stress and supports cell viability.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,27(6).
MLA	Li, Kai,et al."Plasma sprayed cerium oxide coating inhibits H2O2-induced oxidative stress and supports cell viability".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 27.6(2016).