DNA-templated microwave-hydrothermal synthesis of nanostructured hydroxyapatite for storing and sustained release of an antibacterial protein | |
Chen, Xi1; Yang, Bin1; Qi, Chao2; Sun, Tuan-Wei2; Chen, Feng2; Wu, Jin2; Feng, Xi-Ping1; Zhu, Ying-Jie2 | |
刊名 | DALTON TRANSACTIONS |
2016 | |
卷号 | 45期号:4页码:1648-1656 |
英文摘要 | Hydroxyapatite (HA) is promising in various biomedical applications owing to its similar chemical composition, structure and properties to the inorganic component in natural hard tissues. Herein, we report a DNA-templated microwave-assisted hydrothermal strategy for the preparation of HA nanostructured materials. As a kind of natural biomacromolecule, DNA molecules open up a new way to the synthesis of HA nanostructured materials with well-defined structures and morphologies. The HA nanostructured materials with a nanosheet-assembled hierarchical structure and a HA nanorod ordered structure are successfully prepared. The important roles of DNA molecules and pH values in the formation of HA nanostructured materials are investigated, and a possible formation mechanism is proposed. The as-prepared HA nanostructured materials exhibit a relatively high adsorption ability for chicken immunoglobulin Y (IgY) protein and a sustained protein release behavior. The as-prepared HA nanostructured materials after loading the IgY protein show a high antimicrobial activity. Thus, the HA nanostructured materials prepared by the DNA-templated microwave hydrothermal method are promising for the applications in various areas such as the prevention and treatment of dental caries. |
WOS标题词 | Science & Technology ; Physical Sciences |
类目[WOS] | Chemistry, Inorganic & Nuclear |
研究领域[WOS] | Chemistry |
关键词[WOS] | EGG-YOLK ANTIBODIES ; 5'-TRIPHOSPHATE DISODIUM SALT ; RESPONSIVE DRUG-DELIVERY ; STREPTOCOCCUS-MUTANS ; DENTAL-CARIES ; MESOPOROUS MICROSPHERES ; PASSIVE-IMMUNIZATION ; PHOSPHORUS SOURCE ; PHOSPHATE ; NANORODS |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000369088000043 |
内容类型 | 期刊论文 |
源URL | [http://ir.sic.ac.cn/handle/331005/23177] |
专题 | 上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文 |
作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Dept Prevent Dent, Peoples Hosp 9, Shanghai 200011, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
推荐引用方式 GB/T 7714 | Chen, Xi,Yang, Bin,Qi, Chao,et al. DNA-templated microwave-hydrothermal synthesis of nanostructured hydroxyapatite for storing and sustained release of an antibacterial protein[J]. DALTON TRANSACTIONS,2016,45(4):1648-1656. |
APA | Chen, Xi.,Yang, Bin.,Qi, Chao.,Sun, Tuan-Wei.,Chen, Feng.,...&Zhu, Ying-Jie.(2016).DNA-templated microwave-hydrothermal synthesis of nanostructured hydroxyapatite for storing and sustained release of an antibacterial protein.DALTON TRANSACTIONS,45(4),1648-1656. |
MLA | Chen, Xi,et al."DNA-templated microwave-hydrothermal synthesis of nanostructured hydroxyapatite for storing and sustained release of an antibacterial protein".DALTON TRANSACTIONS 45.4(2016):1648-1656. |
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