Nanoparticle-enhanced synergistic HIFU ablation and transarterial chemoembolization for efficient cancer therapy

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 高性能陶瓷和超微结构国家重点实验室 > 期刊论文

	Nanoparticle-enhanced synergistic HIFU ablation and transarterial chemoembolization for efficient cancer therapy
	You, Yufeng 1,2,3; Wang, Zhigang 1,2; Ran, Haitao 1,2; Zheng, Yuanyi 1,2; Wang, Dong 4; Xu, Jinshun 1,2; Wang, Zhibiao 5; Chen, Yu 6; Li, Pan 1,2
刊名	NANOSCALE
	2016
卷号	8 期号:7 页码:4324-4339
英文摘要	High-intensity focused ultrasound (HIFU) is being generally explored as a non-invasive therapeutic modality to treat solid tumors. However, the clinical use of HIFU for large and deep tumor-ablation applications such as hepatocellular carcinoma (HCC) is currently entangled with long treatment duration and high operating energy. This critical issue can be potentially resolved by the introduction of HIFU synergistic agents (SAs). Traditional SAs such as microbubbles and microparticles face the problem of large size, short cycle time, damage to mononuclear phagocytic system and unsatisfactory targeting efficiency. In this work, we have developed a facile and versatile nanoparticle-based HIFU synergistic cancer surgery enhanced by transarterial chemoembolization for high-efficiency HCC treatment based on elaborately designed Fe3O4-PFH/PLGA nanocapsules. Multifunctional Fe3O4-PFH/PLGA nanocapsules were administrated into tumor tissues via transarterial injection combined with Lipiodol to achieve high tumor accumulation because transarterial chemoembolization by Lipiodol could block the blood vessels. The high synergistic HIFU ablation effect was successfully achieved against HCC tumors based on the phase-transformation performance of the perfluorohexane (PFH) inner core in the composite nanocapsules, as systematically demonstrated in VX2 liver tumor xenograft in rabbits. Multifunctional Fe3O4-PFH/PLGA nanocapsules were also demonstrated as efficient contrast agents for ultrasound, magnetic resonance and photoacoustic tri-modality imagings, potentially applicable for imaging-guided HIFU synergistic surgery. Therefore, the elaborate integration of traditional transarterial chemoembolization with recently developed nanoparticle-enhanced HIFU cancer surgery could efficiently enhance the HCC cancer treatment outcome, initiating a new and efficient therapeutic protocol/modality for clinic cancer treatment.
WOS标题词	Science & Technology ; Physical Sciences ; Technology
类目[WOS]	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]	INTENSITY FOCUSED ULTRASOUND ; MESOPOROUS SILICA NANOPARTICLES ; IRON-OXIDE NANOPARTICLES ; HEPATOCELLULAR-CARCINOMA ; DRUG-DELIVERY ; CONTRAST AGENTS ; TUMOR ABLATION ; IN-VIVO ; ARTERIAL EMBOLIZATION ; CLINICAL-EXPERIENCE
收录类别	SCI
语种	英语
WOS记录号	WOS:000370761700055
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/23200]
专题	上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文
作者单位	1.Chongqing Med Univ, Chongqing Key Lab Ultrasound Mol Imaging, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing 400010, Peoples R China 2.Chongqing Med Univ, Chongqing Key Lab Ultrasound Mol Imaging, Affiliated Hosp 2, Dept Ultrasound, Chongqing 400010, Peoples R China 3.Cent Hosp Enshi Autonomous Prefecture, Dept Radiol, Hubei 445000, Peoples R China 4.Chongqing Med Univ, Childrens Hosp, Dept Ultrasound, Chongqing 400014, Peoples R China 5.Chongqing Med Univ, Coll Biomed Engn, Chongqing 400016, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	You, Yufeng,Wang, Zhigang,Ran, Haitao,et al. Nanoparticle-enhanced synergistic HIFU ablation and transarterial chemoembolization for efficient cancer therapy[J]. NANOSCALE,2016,8(7):4324-4339.
APA	You, Yufeng.,Wang, Zhigang.,Ran, Haitao.,Zheng, Yuanyi.,Wang, Dong.,...&Li, Pan.(2016).Nanoparticle-enhanced synergistic HIFU ablation and transarterial chemoembolization for efficient cancer therapy.NANOSCALE,8(7),4324-4339.
MLA	You, Yufeng,et al."Nanoparticle-enhanced synergistic HIFU ablation and transarterial chemoembolization for efficient cancer therapy".NANOSCALE 8.7(2016):4324-4339.