Brain quantitative proteomic responses reveal new insight of benzotriazole neurotoxicity in female Chinese rare minnow (Gobiocypris rarus)

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境水质学国家重点实验室

	Brain quantitative proteomic responses reveal new insight of benzotriazole neurotoxicity in female Chinese rare minnow (Gobiocypris rarus)
	Liang, Xuefang; Martyniuk, Christopher J.; Zha, Jinmiao; Wang, Zijian
刊名	AQUATIC TOXICOLOGY
	2016-12
卷号	181 期号:0 页码:67-75
关键词	Neurotoxicity Benzotriazole Rare minnow (Gobiocypris rarus) Brain proteome
英文摘要	Benzotriazole (BT) is a high-production volume chemical which has been ubiquitously detected in aquatic environments. Although adverse effects from acute and chronic exposure to BT have been reported, the neurotoxic effect of BT and the mechanisms of toxicity are not well documented. In this study, adult female Chinese rare minnow (Gobiocypris rarus) were exposed to 0.05, 0.5, and 5 mg/L BT for 28 days. The brain proteome showed that BT exposure mainly involved in metabolic process, signal transduction, stress response, cytoskeleton, and transport. Pathway analysis revealed that cellular processes affected by BT included cellular respiration, G-protein signal cascades, Ca2+-dependent signaling, cell cycle and apoptosis. Moreover, data on relative mRNA levels demonstrated that genes related to these toxic pathways were also significantly affected by BT. Furthermore, proteins affected by BT such as CKBB, GS, HPCA, VDAC1, and FLOT1A are associated with neurological disorders. Therefore, our finding suggested that BT induced molecular responses in the brain and could provide new insight into BT neurotoxicity in Chinese rare minnow. (C) 2016 Elsevier B.V. All rights reserved.
收录类别	SCI
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/36014]
专题	生态环境研究中心_环境水质学国家重点实验室
推荐引用方式 GB/T 7714	Liang, Xuefang,Martyniuk, Christopher J.,Zha, Jinmiao,et al. Brain quantitative proteomic responses reveal new insight of benzotriazole neurotoxicity in female Chinese rare minnow (Gobiocypris rarus)[J]. AQUATIC TOXICOLOGY,2016,181(0):67-75.
APA	Liang, Xuefang,Martyniuk, Christopher J.,Zha, Jinmiao,&Wang, Zijian.(2016).Brain quantitative proteomic responses reveal new insight of benzotriazole neurotoxicity in female Chinese rare minnow (Gobiocypris rarus).AQUATIC TOXICOLOGY,181(0),67-75.
MLA	Liang, Xuefang,et al."Brain quantitative proteomic responses reveal new insight of benzotriazole neurotoxicity in female Chinese rare minnow (Gobiocypris rarus)".AQUATIC TOXICOLOGY 181.0(2016):67-75.