Fragmentation Study of Daphniphyllum Alkaloids by Electrospray Ionization Quadrupole Time-of-flight Mass Spectrometry

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	Fragmentation Study of Daphniphyllum Alkaloids by Electrospray Ionization Quadrupole Time-of-flight Mass Spectrometry
	Cao, Min-Min 1,3,4; Wang, Dan 5,6; Zhang, Hao 1; Fang, Dong-Mei 2; He, Hong-Ping 1,2,3; Hao, Xiao-Jiang3 ; Zhang, Guo-Lin 2; Wu, Zhi-Jun 2
刊名	CURRENT PHARMACEUTICAL ANALYSIS
	2016
卷号	12 期号:3 页码:249-257
关键词	Daphniphyllum alkaloids electrospray ESI-QTOF six-member H rearrangement fragmentation isomers
英文摘要	A series of 16 Daphniphyllum alkaloids isolated from Daphniphyllum macropodum were investigated by electrospray ionization quadrupole time-of-flight tandem mass spectrometry (ESI-QTOF-MS/MS) in positive-ion mode. Deuterium labeling experiments were carried out to identify the major product ions. Although compounds have similar structures, the profiles of their MS/MS spectra vary greatly. For compounds 1 and 2, abundant product ions both in high and low mass range can be detected. A six-member H rearrangement and the cleavage of C1-C2 bond connecting rings A, C and D play an important role in providing the product ions in low mass range. For compounds 3-9, the relative abundance of product ions in low mass range is low. This may result from the loss of HCOOCH3 occurring readily because C4-C5 double bond prevents six-member H rearrangement. Main fragmentation patterns of compounds 10-14 are the loss of the different side-chain groups and the cleavage of pyrrol and pyridine rings. A series of ion clusters detected in low mass range are characteristic ions for compounds 10-14. Fragmentation patterns of compounds 15 and 16 were elucidated. Four groups of isomers in these compounds were distinguished by characteristic product ions or fragmentation patterns.
类目[WOS]	Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	MACROPODUM MIQ ; ESI-MS/MS ; HUMILE
收录类别	SCI
语种	英语
WOS记录号	WOS:000384722100012
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/33617]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Yunnan Univ, Sch Pharm, TCM, Kunming, Peoples R China 2.Chinese Acad Sci, Chengdu Inst Biol, Box 610041, Chengdu, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China 4.Univ Chinese Acad Sci Beijing, Beijing, Peoples R China 5.Chengdu Univ, Chengdu, Peoples R China 6.Sichuan Univ, West China Sch Pharm, Chengdu, Peoples R China
推荐引用方式 GB/T 7714	Cao, Min-Min,Wang, Dan,Zhang, Hao,et al. Fragmentation Study of Daphniphyllum Alkaloids by Electrospray Ionization Quadrupole Time-of-flight Mass Spectrometry[J]. CURRENT PHARMACEUTICAL ANALYSIS,2016,12(3):249-257.
APA	Cao, Min-Min.,Wang, Dan.,Zhang, Hao.,Fang, Dong-Mei.,He, Hong-Ping.,...&Wu, Zhi-Jun.(2016).Fragmentation Study of Daphniphyllum Alkaloids by Electrospray Ionization Quadrupole Time-of-flight Mass Spectrometry.CURRENT PHARMACEUTICAL ANALYSIS,12(3),249-257.
MLA	Cao, Min-Min,et al."Fragmentation Study of Daphniphyllum Alkaloids by Electrospray Ionization Quadrupole Time-of-flight Mass Spectrometry".CURRENT PHARMACEUTICAL ANALYSIS 12.3(2016):249-257.