Six new physalins from Physalis alkekengi var. franchetii and their cytotoxicity and antibacterial activity

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Six new physalins from Physalis alkekengi var. franchetii and their cytotoxicity and antibacterial activity
	Yang, Ye-Kun 1,2; Xie, Si-da 1; Xu, Wan-xuan 1; Nian, Yin1 ; Liu, Xiao-Ling 1; Peng, Xing-Rong 1; Ding, Zhong-Tao 2; Qiu, Ming-Hua1
刊名	FITOTERAPIA
	2016-07-01
卷号	112 页码:144-152
关键词	Physalis alkekengi var. franchetii Steroid Physalin Neophysalin
英文摘要	Six new physalin steroids, 7 beta-methoxylisophysalin B (1), 7 beta-methoxylphysalin C (2), physalin V (3), physalin VI (4), physalin VII (5), isophysalin I (6), together with 20 known physalins (7-26) were isolated from calyces of Physalis alkekengi var. franchetii. Structures of the new compounds were revealed through 10 and 2D NMR and mass spectroscopic methods. Compounds 1-26 were evaluated for cytotoxicity against human HL-60, SMMC-7721, A-549, MCF-7 and SW-480, and the results indicated that compounds 8,11, and 14 displayed-potent cytotoxicities (IC50 < 5 mu M) in vitro. Further antibacterial assay indicated that compounds 8,14, and 19 showed high antibacterial activities against Bacillus subtilis and Escherichia coli. (C) 2016 Elsevier B.V. All rights reserved.
类目[WOS]	Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	IMMUNOSUPPRESSIVE ACTIVITY ; BITTER PRINCIPLES ; ANGULATA ; LANCIFOLIA ; WITHANOLIDES ; NEOPHYSALINS ; MINIMA ; PLANTS
收录类别	SCI
语种	英语
WOS记录号	WOS:000380865400018
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/33598]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Yang, Ye-Kun,Xie, Si-da,Xu, Wan-xuan,et al. Six new physalins from Physalis alkekengi var. franchetii and their cytotoxicity and antibacterial activity[J]. FITOTERAPIA,2016,112:144-152.
APA	Yang, Ye-Kun.,Xie, Si-da.,Xu, Wan-xuan.,Nian, Yin.,Liu, Xiao-Ling.,...&Qiu, Ming-Hua.(2016).Six new physalins from Physalis alkekengi var. franchetii and their cytotoxicity and antibacterial activity.FITOTERAPIA,112,144-152.
MLA	Yang, Ye-Kun,et al."Six new physalins from Physalis alkekengi var. franchetii and their cytotoxicity and antibacterial activity".FITOTERAPIA 112(2016):144-152.