QQ客服 官方微博 反馈留言

	Effects of High-Fat Diet on The Reproductive System of Immature Female Mice
	Binbin Huang; Xiaoyun Qin; Jian V Zhang
	2016
会议名称	The 4th SKLRB Symposium on Reproductive Biology
会议地点	中国北京
英文摘要	Being overweight or obese increases the relative risk of many diseases in women for example, diabetes, low back pain, and sterility which causes lots of attention these years. By now, how dose obesity affect the progression of reproductive system, especially in the young women, remains unknown. To explore more hints for answering this question, we set up high-fat diet (HFD) model in immature C57/BL6 female mice to characterize the effects of HFD on body weight, estrous cycle, serum hormone levels, serum biochemical indexes gene expression in ovary and pituitary. Besides, we also measured the expression levels of mRNA and lncRNA in gonadal white adipose tissue (WAT) and ovaries use microarray. Our results showed that HFD can significantly increase the body weights of mice, and induce irregular estrous cycles in young female mice. Both FSH and LH expression were significant decrease in pituitaries of HFD mice. Oxidative stress and apoptosis-related genes, including GSH-Px, CAT, and caspase3, caspase9 in HFD ovaries compared with ovaries in chow mice. HFD induced 99 mRNA and 64 lncRNA up regulation, and 200 mRNA and 235 lncRNA down regulation with 1.3 times fold change in ovaries. HFD induced 57 mRNA and 199 lncRNA up regulation, and 136 mRNA and few lncRNA down regulation with 1.5 times fold change in gonadal white adipose tissue. These results may offer a research basis for future investigating the roles of obesity on reproductive system.
收录类别	其他
语种	英语
内容类型	会议论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10834]
专题	深圳先进技术研究院_医药所
作者单位	2016
推荐引用方式 GB/T 7714	Binbin Huang,Xiaoyun Qin,Jian V Zhang. Effects of High-Fat Diet on The Reproductive System of Immature Female Mice[C]. 见:The 4th SKLRB Symposium on Reproductive Biology. 中国北京.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。