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	Abnormal bone mineral in serum and bone mineral density following steroid administration in the early pathogenesis of steroid-induced osteonecrosis
	Lei Wang; Li Zhang; Haobo Pan; Songlin Peng; William Weijia Lu
	2015
会议名称	The 36th SICOT Orthopaedic World Congress (Guangzhou OWC 2015)
会议地点	广东广州
英文摘要	Non-traumatic osteonecrosis (ON) of the femoral head, which occurs frequently in young and middle-aged patients (30 to 50 years old), progresses rapidly and has a high disability rate (1). One of the most common risk factors for non-traumatic ON is steroid administration for the treatment of diseases such as Systemic Lupus Erythematosus, nephrotic syndrome and renal transplantation (2). Owing to the various effects of steroids on multi-system pathways involved in osteoblast differentiation, osteoblast and osteoclast apoptosis, lipid metabolism, calcium metabolism, and coagulation, it has been challenging to fully elucidate the pathogenesis and etiology of steroid-induced ON . Steroids excess can directly act on bone cells to decrease the production of osteoblasts and osteoclasts, suppress production of osteoblast and osteoclast precursor, increase apoptosis of osteoblasts and osteocytes, and prolong the lifespan of osteoclasts.
收录类别	其他
语种	英语
内容类型	会议论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7473]
专题	深圳先进技术研究院_医药所
作者单位	2015
推荐引用方式 GB/T 7714	Lei Wang,Li Zhang,Haobo Pan,et al. Abnormal bone mineral in serum and bone mineral density following steroid administration in the early pathogenesis of steroid-induced osteonecrosis[C]. 见:The 36th SICOT Orthopaedic World Congress (Guangzhou OWC 2015). 广东广州.

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