QQ客服 官方微博 反馈留言

	Electrospun nanoporous PDLLA fiber accelerates drug release
	Shuai wu; Jianhui Yue; Di Liu; Xiaoli Zhao; Haobo Pan
	2015
会议名称	5th China-Europe Symposium on Biomaterials in Regenerative Medicine, CESB
会议地点	浙江杭州
英文摘要	Biocompatible nanofibers have become increasingly important for clinical applications in recent years for their ability in adapting to physiological conditions of the human body. Electrospun fibers could be used as drug delivery device because of their inherent high specific surface area and high porous[1], but the initial release and cumulative release were less. Through modifying the surface morphology of electrospun fibers for drug delivery, matrix porosity and increased surface area of the fibers allow the tuning of drug release profiles [2]. In this study, Poly-DL-lactide(PDLLA) fibers were produced by electrospun using a variety of solvents to obtain nanoporous surface, and the surface morphology as well as the drug release properties were investigated. Observed by scanning electron microscopy(SEM), it could be found that the size of pores on nanoporous fibers were in the range 20～280nm. These pores were only present in the surface. The mechanical properties of the fibers were examined and the result showed that the tensile strengthof nanoporous fibers was less than the smooth surface fibers, but it showed higher tensile failure strain. Using rifampin as the drug model, it could be observed that the initial and cumulative release amount of rifampin loaded in nanoporous fibers was obviously higher than the smooth fibers. The difference here was attributed to the different surface area which affected the drug release rate. This could also be demonstrated by rifampin adsorption. This study showed that nanoporous surface fibersaccelerated drug release andwere more suitable as a drug carrierthan smooth surface fibers.
收录类别	其他
语种	英语
内容类型	会议论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7471]
专题	深圳先进技术研究院_医药所
作者单位	2015
推荐引用方式 GB/T 7714	Shuai wu,Jianhui Yue,Di Liu,et al. Electrospun nanoporous PDLLA fiber accelerates drug release[C]. 见:5th China-Europe Symposium on Biomaterials in Regenerative Medicine, CESB. 浙江杭州.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。