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	Translational Nanomedicine for Imaging-Guided Photothermal Therapy
	Zonghai Sheng; Mingbin Zheng; Lintao Cai
	2015
会议名称	ChinaNanomedicine 2015
会议地点	Hangzhou, China
英文摘要	Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), is a light-activated treatment modality that is under intensive preclinical and clinical investigations for cancer therapy. To enhance the treatment efficiency of phototherapy and reduce the light-associated side effects, it is highly desirable to improve drug accumulation and precision guided phototherapy for efficient conversion of the absorbed light energy to reactive oxygen species (ROS) and hyperthermia. We reported here several functional theranostic nanomedicines design for cancer imaging and targeted phototherapy in vivo. The polymer-lipid hybrid nanoparticles (DINPs) were used to simultaneously deliver DOX and indocyanine green (ICG) to tumor regions for combined chemo-photothermal therapy, which not only synergistically induced DOX-sensitive MCF-7 or DOX resistant MCF-7/ADR cell death in vitro, but also highly suppressed MCF-7 or MCF-7/ADR tumor growth and effectively prevented tumor recurrence in vivo. We slao developed a programmed assembly strategy using the human serum albumin (HSA)-indocyanine green (ICG) nanoprobes for imaging-guided cancer synergistic phototherapy. The tumor and its margin were clearly identified, and the smart HAS-ICG nanoprobe efficiently induced ROS and local hyperthermia simultaneously for synergetic PDT/PTT in a single dose treatment.
收录类别	其他
语种	英语
WOS记录号	WOS:000373923400356
内容类型	会议论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7440]
专题	深圳先进技术研究院_医药所
作者单位	2015
推荐引用方式 GB/T 7714	Zonghai Sheng,Mingbin Zheng,Lintao Cai. Translational Nanomedicine for Imaging-Guided Photothermal Therapy[C]. 见:ChinaNanomedicine 2015. Hangzhou, China.

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