A novel bioceramic scaffold integrating silk fibroin in calcium polyphosphate for bone tissue-engineering

	A novel bioceramic scaffold integrating silk fibroin in calcium polyphosphate for bone tissue-engineering
	Xie, Huixu; Gu, Zhipeng; Li, Chuansong; Franco, Christopher; Wang, Jianyun; Li, Longjiang; Meredith, Neil; Ye, Qingsong; Wan, Changxiu
刊名	CERAMICS INTERNATIONAL
	2016
英文摘要	The advantages of bioceramics, such as biocompatibility and osteoconduction, have been widely used for bone repair and substitute as bone tissue-engineering materials. Bioceramic scaffolds however still need improvement to meet the requirements for complex bone repair. The aim of this study was to develop novel bioscaffolds for bone regeneration, based on the combination of silk fibroin (SF) and calcium polyphosphate (CPP) composite scaffolds. In this study, Bombyx mori silk fibroin (BMSF) and Antheraea pernyi silk fibroin (APSF) were prepared, and applied into CPP scaffolds with glutaraldehyde crosslinking to form the BMSF/CPP and APSF/CPP bioceramics. These scaffolds were then undergone the strength tests, morphology evaluation, and assessments for biodegradation and biocompatibility. Our results showed that the CPP-type biocemmics presented a higher compressive strength and enhanced degradation after the silk fibroin was doped into a CPP structure. Moreover, the BMSF/CPP and APSF/CPP-type scaffolds exhibited lower cellular toxicity than those of the CPP and HA types. Considering the improved mechanical characteristics and degradation as well as ready availability, SF/CPP may be considered a suitable bioceramic for bone tissue-engineering. (C) 2015 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
收录类别	SCI
原文出处	http://www.sciencedirect.com/science/article/pii/S0272884215019148
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10762]
专题	深圳先进技术研究院_医药所
作者单位	CERAMICS INTERNATIONAL
推荐引用方式 GB/T 7714	Xie, Huixu,Gu, Zhipeng,Li, Chuansong,et al. A novel bioceramic scaffold integrating silk fibroin in calcium polyphosphate for bone tissue-engineering[J]. CERAMICS INTERNATIONAL,2016.
APA	Xie, Huixu.,Gu, Zhipeng.,Li, Chuansong.,Franco, Christopher.,Wang, Jianyun.,...&Wan, Changxiu.(2016).A novel bioceramic scaffold integrating silk fibroin in calcium polyphosphate for bone tissue-engineering.CERAMICS INTERNATIONAL.
MLA	Xie, Huixu,et al."A novel bioceramic scaffold integrating silk fibroin in calcium polyphosphate for bone tissue-engineering".CERAMICS INTERNATIONAL (2016).