Docetaxel (DTX)-loaded polydopamine-modified TPGS-PLA nanoparticles as a targeted drug delivery system fore the treatment of liver cancer

	Docetaxel (DTX)-loaded polydopamine-modified TPGS-PLA nanoparticles as a targeted drug delivery system fore the treatment of liver cancer
	Zhu,Dunwan; Tao,Wei; Zhang,Hongling; Liu,Gan; Wang,Teng; Zhang,Linhua; Zeng,Xiaowei; Mei,Lin
刊名	ACTA BIOMATERIALIA
	2016
英文摘要	Polydopamine-based surface modification is a simple way to functionalize polymeric nanoparticle (NP) surfaces with ligands and/or additional polymeric layers. In this work, we developed DTX-loaded formulations using polydopamine-modified NPs synthesized using D-a-tocopherol polyethylene glycol 1000 succinate-poly(lactide) (pD-TPGS-PLA/NPs). To target liver cancer cells, galactosamine was conjugated on the prepared NPs (Gal-pD-TPGS-PLA/NPs) to enhance the delivery of DTX via ligand-mediated endocytosis. The size and morphology of pD-TPGS-PLA/NPs and Gal-pD-TPGS-PLA/NPs changed obviously compared with TPGS-PLA/NPs. In vitro studies showed that TPGS-PLA/NPs, pD-TPGS-PLA/NPs and Gal-pD-TPGS-PLA/NPs had similar release profiles of DTX. Both confocal laser scanning microscopy and flow cytometric results showed that coumarin 6-loaded Gal-pD-TPGS-PLA/NPs had the highest cellular uptake efficiency in liver cancer cell line HepG2. Moreover, DTX-loaded Gal-pD-TPGS-PLA/NPs inhibited the growth ofHepG2 cells more potently than TPGS-PLA/NPs, pD-TPGS-PLA/NPs, and a clinically available DTX formulation (Taxotere). The in vivo biodistribution experiments show that the Gal-pD-TPGS-PLA/NPs are specifically targeted to the tumor. Furthermore, the in vivo anti-tumor effects study showed that injecting DTX-loaded Gal-pD-TPGS-PLA/NPs reduced the tumor size most significantly on hepatoma-bearing nude mice. These results suggest that Gal-pD-TPGS-PLA/NPs prepared in the study specifically interacted with the hepatocellular carcinoma cells through ligand-receptor recognition and they may be used as a potentially eligible drug delivery system targeting liver cancers.
收录类别	SCI
原文出处	http://www.sciencedirect.com/science/article/pii/S1742706115302063
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10721]
专题	深圳先进技术研究院_医药所
作者单位	ACTA BIOMATERIALIA
推荐引用方式 GB/T 7714	Zhu,Dunwan,Tao,Wei,Zhang,Hongling,et al. Docetaxel (DTX)-loaded polydopamine-modified TPGS-PLA nanoparticles as a targeted drug delivery system fore the treatment of liver cancer[J]. ACTA BIOMATERIALIA,2016.
APA	Zhu,Dunwan.,Tao,Wei.,Zhang,Hongling.,Liu,Gan.,Wang,Teng.,...&Mei,Lin.(2016).Docetaxel (DTX)-loaded polydopamine-modified TPGS-PLA nanoparticles as a targeted drug delivery system fore the treatment of liver cancer.ACTA BIOMATERIALIA.
MLA	Zhu,Dunwan,et al."Docetaxel (DTX)-loaded polydopamine-modified TPGS-PLA nanoparticles as a targeted drug delivery system fore the treatment of liver cancer".ACTA BIOMATERIALIA (2016).