Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity

	Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity
	Liu, Ke; Lei, Run; Li, Qiong; Wang, Xin-Xin; Wu, Qian; An, Peng; Zhang, Jianchao; Zhu, Minyan; Xu, Zhiheng; Hong, Yang
刊名	SCIENTIFIC REPORTS
	2016
英文摘要	Transferrin receptor (TFR) is an important iron transporter regulating iron homeostasis and has long been used as a marker for clathrin mediated endocytosis. However, little is known about its additional function other than iron transport in the development of central nervous system (CNS). Here we demonstrate that TFR functions as a regulator to control AMPA receptor trafficking efficiency and synaptic plasticity. The conditional knockout (KO) of TFR in neural progenitor cells causes mice to develop progressive epileptic seizure, and dramatically reduces basal synaptic transmission and long-term potentiation (LTP). We further demonstrate that TFR KO remarkably reduces the binding efficiency of GluR2 to AP2 and subsequently decreases AMPA receptor endocytosis and recycling. Thus, our study reveals that TFR functions as a novel regulator to control AMPA trafficking efficiency and synaptic plasticity.
收录类别	SCI
原文出处	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754636/
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10684]
专题	深圳先进技术研究院_医药所
作者单位	SCIENTIFIC REPORTS
推荐引用方式 GB/T 7714	Liu, Ke,Lei, Run,Li, Qiong,et al. Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity[J]. SCIENTIFIC REPORTS,2016.
APA	Liu, Ke.,Lei, Run.,Li, Qiong.,Wang, Xin-Xin.,Wu, Qian.,...&Li, Huashun.(2016).Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity.SCIENTIFIC REPORTS.
MLA	Liu, Ke,et al."Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity".SCIENTIFIC REPORTS (2016).