Fully Automated Synthesis of DNA-Binding Py-Im Polyamides Using a Triphosgene Coupling Strategy

	Fully Automated Synthesis of DNA-Binding Py-Im Polyamides Using a Triphosgene Coupling Strategy
	Lijing Fang; Guiyang Yao; Zhengyin Pan; Chunlei Wu; Heng-Shan Wang; Glenn A Burley; Wu Su
刊名	Organic Letters
	2015
英文摘要	The fully automated solid-phase synthetic strategy of hairpin pyrrole−imidazole polyamides is described. A key advance is the development of methodology for the application of triphosgene as a coupling agent in the automated synthesis of hairpin polyamides without racemization. This automated methodology is compatible with all the typical building blocks, enabling the facile synthesis of polyamide libraries in good yield (9−15%) and crude purity.
收录类别	SCI
原文出处	http://pubs.acs.org/doi/pdf/10.1021/ol503388a
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7340]
专题	深圳先进技术研究院_医药所
作者单位	Organic Letters
推荐引用方式 GB/T 7714	Lijing Fang,Guiyang Yao,Zhengyin Pan,et al. Fully Automated Synthesis of DNA-Binding Py-Im Polyamides Using a Triphosgene Coupling Strategy[J]. Organic Letters,2015.
APA	Lijing Fang.,Guiyang Yao.,Zhengyin Pan.,Chunlei Wu.,Heng-Shan Wang.,...&Wu Su.(2015).Fully Automated Synthesis of DNA-Binding Py-Im Polyamides Using a Triphosgene Coupling Strategy.Organic Letters.
MLA	Lijing Fang,et al."Fully Automated Synthesis of DNA-Binding Py-Im Polyamides Using a Triphosgene Coupling Strategy".Organic Letters (2015).