Factors Impacting the Formation of Sphere-Like Bacterial Cellulose Particles and Their Biocompatibility for Human Osteoblast Growth

	Factors Impacting the Formation of Sphere-Like Bacterial Cellulose Particles and Their Biocompatibility for Human Osteoblast Growth
	Yang Hu; Jeﬀrey M. Catchmark; Erwin A. Vogler
刊名	BIOMACROMOLECULES
	2013
英文摘要	It has been observed that certain strains of the bacterium Gluconacetobacter xylinus can produce sphere-like cellulose particles (SCP) under orbital shaking cultivation. These unique particles may have broad applications in materials science, especially in the biomedical field. The mechanism behind SCP formation and SCP biocompatibility, however, remain unknown. In this study, several factors potentially involved in the formation of SCP have been examined including the composition of initial inoculums, inoculum volume, initial media glucose concentration, and temperature. The results revealed that cellulose fibers supposedly existing in the initial inoculums did not relate to the initiation of cellulose spherical structure. Increased inoculum volume reduced the number of SCP, and different initial glucose concentrations impacted the mean of approximate diameters of SCP, while the number of SCP remained unchanged under different initial glucose concentrations. Additionally, the formation process of SCP has been clearly identified in this study by lowering the culture temperature. Furthermore, rapid attachment and extension of human osteoblast cells grown on SCP demonstrated their good biocompatibility and the potential use of this kind of materials for biomedical applications.
收录类别	SCI
原文出处	http://pubs.acs.org/doi/abs/10.1021/bm400744a
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/5205]
专题	深圳先进技术研究院_医药所
作者单位	BIOMACROMOLECULES
推荐引用方式 GB/T 7714	Yang Hu,Jeﬀrey M. Catchmark,Erwin A. Vogler. Factors Impacting the Formation of Sphere-Like Bacterial Cellulose Particles and Their Biocompatibility for Human Osteoblast Growth[J]. BIOMACROMOLECULES,2013.
APA	Yang Hu,Jeﬀrey M. Catchmark,&Erwin A. Vogler.(2013).Factors Impacting the Formation of Sphere-Like Bacterial Cellulose Particles and Their Biocompatibility for Human Osteoblast Growth.BIOMACROMOLECULES.
MLA	Yang Hu,et al."Factors Impacting the Formation of Sphere-Like Bacterial Cellulose Particles and Their Biocompatibility for Human Osteoblast Growth".BIOMACROMOLECULES (2013).