Epigenetic disruption of cell signaling in nasopharyngeal carcinoma

	Epigenetic disruption of cell signaling in nasopharyngeal carcinoma
	LiLi Li; XingSheng Shu; ZhaoHui Wang; Ya Cao; Qian Tao
刊名	Chinese journal of cancer癌症
	2011
卷号	30 期号:4 页码:231-239
英文摘要	Nasopharyngeal carcinoma (NPC) is a malignancy with remarkable ethnic and geographic distribution in southern China and Southeast Asia. Alternative to genetic changes, aberrant epigenetic events disrupt multiple genes involved in cell signaling pathways through DNA methylation of promoter CpG islands and/or histone modifications. These epigenetic alterations grant cell growth advantage and contribute to the initiation and progression of NPC. In this review, we summarize the epigenetic deregulation of cell signaling in NPC tumorigenesis and highlight the importance of identifying epigenetic cell signaling regulators in NPC research. Developing pharmacologic strategies to reverse the epigenetic-silencing of cell signaling regulators might thus be useful to NPC prevention and therapy.
收录类别	CSCD
原文出处	http://europepmc.org/articles/pmc4013349
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/3648]
专题	深圳先进技术研究院_医药所
作者单位	Chinese journal of cancer癌症
推荐引用方式 GB/T 7714	LiLi Li,XingSheng Shu,ZhaoHui Wang,et al. Epigenetic disruption of cell signaling in nasopharyngeal carcinoma[J]. Chinese journal of cancer癌症,2011,30(4):231-239.
APA	LiLi Li,XingSheng Shu,ZhaoHui Wang,Ya Cao,&Qian Tao.(2011).Epigenetic disruption of cell signaling in nasopharyngeal carcinoma.Chinese journal of cancer癌症,30(4),231-239.
MLA	LiLi Li,et al."Epigenetic disruption of cell signaling in nasopharyngeal carcinoma".Chinese journal of cancer癌症 30.4(2011):231-239.