Protective effect of melatonin on 3-NP induced striatal interneuron injury in rats

	Protective effect of melatonin on 3-NP induced striatal interneuron injury in rats
	Mu Shuhua; OuYang Lisi; Liu Bingbing; Zhu Yaxi; Li Keyi; Zhan Mali; Liu Zongwei; Jia Yu; Lei Wanlong
刊名	Neurochemistry International
	2011
卷号	59 期号:2 页码:224-234
英文摘要	To confirm the effect of melatonin on 3-nitropropionic acid (3-NP)-induced striatal interneuron injury in rats, behavioral test, histology, immunohistochemistry and Western blotting were respectively used to characterize the behavioral changes of experimental animals in motor and cognition, the morphological changes of striatal interneurons and the expression level of protein markers induced by 3-NP. The results showed that (1) 3-NP induced dysfunction ofexperimental animals in movement, motor coordination and cognition could be relieved by melatonin treatment; (2) The 3-NP-induced lesion area was unvaryingly in dorsolateral striatum, with almost all neuronal loss in the lesion core, however, lots of neurons survived after melatonin treatment; (3) Immunohistochemical staining of the four interneuron types (parvalbu-minergic, cholinergic, calretinergic, and neuropeptide Y-neuronal nitric oxide synthase co-containing) showed that, in the lesion core of 3-NP group, loss of the four interneuron types was obvious, but in transition zone, the processes and varicositiesof calretinergic, and neuropeptide Y-neuronal nitric oxide synthase co-containing interneurons increased significantly. Melatonin treatment reduced the loss ofthe four interneuron types in the lesion core, and inhibited the increase of processes and varicosities in the transition zone; (4) Consistent with above results, the expression level of five interneuron protein markers were significantly increased in the striatum after melatonin treatment. Notably, in both the transition zone and the lesion core induced by 3-NP, TUNEL-positive cells were detected, but decreased significantly after melatonin treatment. The present results indicate that melatonin effectively protects the striatal neurons against the injury induced by 3-NP in rats. (C) 2011 Elsevier B.V. All rights reserved.
收录类别	SCI
原文出处	http://www.sciencedirect.com/science/article/pii/S0197018611001835
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/3642]
专题	深圳先进技术研究院_医药所
作者单位	Neurochemistry International
推荐引用方式 GB/T 7714	Mu Shuhua,OuYang Lisi,Liu Bingbing,et al. Protective effect of melatonin on 3-NP induced striatal interneuron injury in rats[J]. Neurochemistry International,2011,59(2):224-234.
APA	Mu Shuhua.,OuYang Lisi.,Liu Bingbing.,Zhu Yaxi.,Li Keyi.,...&Lei Wanlong.(2011).Protective effect of melatonin on 3-NP induced striatal interneuron injury in rats.Neurochemistry International,59(2),224-234.
MLA	Mu Shuhua,et al."Protective effect of melatonin on 3-NP induced striatal interneuron injury in rats".Neurochemistry International 59.2(2011):224-234.