Ultrasound and fragility fracture: is there a role?

	Ultrasound and fragility fracture: is there a role?
	Cheung, Wing-Hoi; Leung, Kwok-Sui; Chow, Simon Kwoon-Ho
刊名	INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
	2016
英文摘要	Osteoporotic fracture is known to have impaired healing capacity and therefore takes longer time to heal, as compared with younger one. The mechanism of impaired osteoporotic fracture healing is multifactorial, where lower responsiveness to mechanical loading is generally believed to be one factor, yet not absolutely confirmed. In recent years, low intensity pulsed ultrasound (LIPUS) is demonstrated to have good efficacy in treating normalfracture healing, as proven by many randomized controlled trials, as well as in vitro and animal evidences. The effects of LIPUS on osteoporotic fracturehealing was also validated in an animal study, which revealed that osteoporotic fractured bone of SD rats showed radiologically and biomechanically comparable responses to LIPUS as age-matched normal fracture healing, in terms of callus width, bridging rate, bone volume fraction, and stiffness etc. Gene expression profiling also confirmed that osteoporotic fractured bone responded to LIPUS very well by upregulating Col1 and BMP2 (osteogenesis) at early phase, VEGF (angiogenesis) at middle phase and RANKL (remodeling) at late phase. These confirm that osteoporotic bones respond well to LIPUS as good as normal bone. These findings may be associated with estrogen receptors (ERs), as estrogen depletion is sensed and relayed by ERs and ERs also function as mechano-sensors. A previous study observed a delayed ERs expression pattern in fracture callus of OVX rats, as compared with SHAM rats, which correlated well with the expression pattern of BMP-2 (callus formation-related gene). Hence, the responses of osteoporotic fractured bone to LIPUS may be related to the local ERs expression at fracture callus that needs further experiments to validate.
收录类别	SCI
原文出处	http://www.sciencedirect.com/science/article/pii/S0020138316300109
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10522]
专题	深圳先进技术研究院_医工所
作者单位	INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
推荐引用方式 GB/T 7714	Cheung, Wing-Hoi,Leung, Kwok-Sui,Chow, Simon Kwoon-Ho. Ultrasound and fragility fracture: is there a role?[J]. INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED,2016.
APA	Cheung, Wing-Hoi,Leung, Kwok-Sui,&Chow, Simon Kwoon-Ho.(2016).Ultrasound and fragility fracture: is there a role?.INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED.
MLA	Cheung, Wing-Hoi,et al."Ultrasound and fragility fracture: is there a role?".INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2016).