Fabrication, characterization and biomedical application of two-nozzle electrospun polycaprolactone/zein-calcium lactate composite nonwoven mat

	Fabrication, characterization and biomedical application of two-nozzle electrospun polycaprolactone/zein-calcium lactate composite nonwoven mat
	Nina Liao; MaheshKumar Joshi; ArjunPrasad Tiwari; Chan-Hee Park; CheolSang Kim
刊名	Journal of the Mechanical Behavior of Biomedical Materials
	2016
英文摘要	The objective of the current work is to incorporate calcium lactate (CL) into polycaprolactone (PCL)/zein composite micro/nanofibrous scaffolds via electrospinning to engineer bone tissue. In this study, a composite micro/nano fibrous scaffold was fabricated using a single two-nozzle electrospinning system to combine indicative nanofibers from a blended solution of zein-CL and micro-sized fibers from a PCL solution. Incorporation of the CL into the PCL/zein fibers were shown to improve the wettability, tensile strength and biological activity of the composite mats. Moreover, the composite mats have a high efficiency to nucleate calcium phosphate from simulated body fluid (SBF) solution. An in vitro cell culture with osteoblast cells demonstrated that the electrospun composite mats possessed improved biological properties, including a better cell adhesion, spread and proliferation. This study has demonstrated that the PCL/zein-CL composite provides a simple platform to fabricate a new biomimetic scaffold for bone tissue engineering, which can recapitulate both the morphology of extracellular matrix and composition of the bone.
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/j.jmbbm.2016.02.006
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10518]
专题	深圳先进技术研究院_医工所
作者单位	Journal of the Mechanical Behavior of Biomedical Materials
推荐引用方式 GB/T 7714	Nina Liao,MaheshKumar Joshi,ArjunPrasad Tiwari,et al. Fabrication, characterization and biomedical application of two-nozzle electrospun polycaprolactone/zein-calcium lactate composite nonwoven mat[J]. Journal of the Mechanical Behavior of Biomedical Materials,2016.
APA	Nina Liao,MaheshKumar Joshi,ArjunPrasad Tiwari,Chan-Hee Park,&CheolSang Kim.(2016).Fabrication, characterization and biomedical application of two-nozzle electrospun polycaprolactone/zein-calcium lactate composite nonwoven mat.Journal of the Mechanical Behavior of Biomedical Materials.
MLA	Nina Liao,et al."Fabrication, characterization and biomedical application of two-nozzle electrospun polycaprolactone/zein-calcium lactate composite nonwoven mat".Journal of the Mechanical Behavior of Biomedical Materials (2016).