The Impact of the Geometric Characteristics on the Hemodynamics in the Stenotic Coronary Artery

	The Impact of the Geometric Characteristics on the Hemodynamics in the Stenotic Coronary Artery
	Changnong Peng; Xiaoqing Wang; Zhanchao Xian; Xin Liu; Wenhua Huang; Pengcheng Xu; Jinyang Wang
刊名	PLoS One
	2016
英文摘要	The alterations of the hemodynamics in the coronary arteries, which result from patient-specific geometric significances are complex. The effect of the stenosis on the blood flow alteration had been wildly reported, but the combinational contribution from geometric factors required a comprehensive investigation to provide patient-specific information for diagnosis and assisting in the decision on the further treatment strategies. In the present study, we investigated the correlation between hemodynamic parameters and individual geometric factors in the patient-specific coronary arteries. Computational fluid dynamic simulations were performed on 22 patient-specific 3-dimensional coronary artery models that were reconstructed based on computed tomography angiography images. Our results showed that the increasing severity of the stenosis is associated with the increased maximum wall shear stress at the stenosis region (r = 0.752, P < 0.001). In contrast, the length of the recirculation zone has a moderate association with the curvature of the lesion segment (r = 0.505, P = 0.019) and the length of the lesions (r = 0.527, P = 0.064). Moreover, bifurcation in the coronary arteries is significantly correlated with the occurrence of recirculation, whereas the severity of distal stenosis demonstrated an effect on the alteration of the flow in the upstream bifurcation. These findings could serve as an indication for treatment planning and assist in prognosis evaluation.
收录类别	SCI
原文出处	http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157490
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10397]
专题	深圳先进技术研究院_医工所
作者单位	PLoS One
推荐引用方式 GB/T 7714	Changnong Peng,Xiaoqing Wang,Zhanchao Xian,et al. The Impact of the Geometric Characteristics on the Hemodynamics in the Stenotic Coronary Artery[J]. PLoS One,2016.
APA	Changnong Peng.,Xiaoqing Wang.,Zhanchao Xian.,Xin Liu.,Wenhua Huang.,...&Jinyang Wang.(2016).The Impact of the Geometric Characteristics on the Hemodynamics in the Stenotic Coronary Artery.PLoS One.
MLA	Changnong Peng,et al."The Impact of the Geometric Characteristics on the Hemodynamics in the Stenotic Coronary Artery".PLoS One (2016).