Dynamic expressions of monocyte chemo attractant protein-1 and CC chamomile receptor 2 after balloon injury and their effects in intimal proliferation

	Dynamic expressions of monocyte chemo attractant protein-1 and CC chamomile receptor 2 after balloon injury and their effects in intimal proliferation
	Huang Zhigang; Li Yuebing; Niu Lili; Xiao Yang; Pu Xiaodong; Zheng Hairong; Qian Ming
刊名	BioMedical Engineering Online
	2015
英文摘要	Objective: The dynamic expressions of monocyte chemo attractant protein-1 (MCP-1) and CC chamomile receptor 2 (CCR2) after balloon injury and their effects in intimal proliferation were discussed. In this study, the expression of MCP-1 and its receptor during the intimal proliferation in rat artery after balloon injury were studied. Methods: Using the model of balloon injury of rats' arteries, the changes of intimal proliferation were observed with optical microscopy and the expressions of MCP-1 and CCR2 at different times were examined with the methods of RT-PCR and immunohistochemistry. The expressions of MCP-1 and CCR2 in the arterial tissues were detected using reverse transcription polymerase chain reaction (RT-PCR) and analyzed by semi-quantitative method. Results: The expressions of MCP-1 and CCR2 mRNA began to gradually increase after balloon injury. The MCP-1 reached to the peak on the first day, but decreased gradually later on. Expressions of CCR2 mRNA began to increase on the first day and reached to the peak on the 7th day, but then started to decrease gradually until 28th day when we can still detect it. The expressions of MCP-1 proteins began to increase gradually after balloon injury and were obviously detected in the VSMC on the 4th and 7th day, until 14th day when we can still detect it clearly in the proliferating intima. Conclusion: The dynamic expressions of MCP-1, MCP-1 proteins and CCR2 mRNA after balloon injury were shown to play an important role in intimal proliferation. © 2015 Huang et al.(30 refs)
收录类别	SCI
原文出处	http://link.springer.com/article/10.1186/s12938-015-0030-8
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7157]
专题	深圳先进技术研究院_医工所
作者单位	BioMedical Engineering Online
推荐引用方式 GB/T 7714	Huang Zhigang,Li Yuebing,Niu Lili,et al. Dynamic expressions of monocyte chemo attractant protein-1 and CC chamomile receptor 2 after balloon injury and their effects in intimal proliferation[J]. BioMedical Engineering Online,2015.
APA	Huang Zhigang.,Li Yuebing.,Niu Lili.,Xiao Yang.,Pu Xiaodong.,...&Qian Ming.(2015).Dynamic expressions of monocyte chemo attractant protein-1 and CC chamomile receptor 2 after balloon injury and their effects in intimal proliferation.BioMedical Engineering Online.
MLA	Huang Zhigang,et al."Dynamic expressions of monocyte chemo attractant protein-1 and CC chamomile receptor 2 after balloon injury and their effects in intimal proliferation".BioMedical Engineering Online (2015).