Stress phase angle depicts differences in arterial stiffness: phantom and in vivo study

	Stress phase angle depicts differences in arterial stiffness: phantom and in vivo study
	Lili Niu; Long Meng; Lisheng Xu; Jia Liu; Qiwen Wang; Yang Xiao; Ming Qian; Hairong Zheng
刊名	PHYSICS IN MEDICINE AND BIOLOGY
	2015
英文摘要	The endothelial cells (ECs) lining of a blood vessel wall are exposed to both the wall shear stress (WSS) of blood flow and the circumferential strain (CS) of pulsing artery wall motion. Both WSS and CS keep involving in the modulation of ECs’ biochemical response and function and the temporal phase angle between the two is called stress phase angle (SPA). Previous studies at the cellular level have indicated that SPA is highly negative at sites that are prone to atherosclerosis, and hypothesized that large SPA may contribute to atherogenesis. Till now, there is no experimental data to support this hypothesis, probably due to the lack of a proper tool for measuring WSS and CS simultaneously and real time. In this study, a non-invasive ultrasonic biomechanics method was utilized to quantitatively calculate the SPA and experimentally evaluate the role of SPA in predicting early atherosclerosis. Three silicon tubes with stiffness of 1.15MPa, 3.62MPa, 9.38MPa were assembled in a pulsatile flow circuit and the values of SPA were measured to be -101.86 ± 3.65°, -170.19 ± 17.77° and -260.63 ± 18.62°, respectively. For the PVA-c phantoms, stiffness was 162.45kPa, 235.68kPa and 374.24kPa, the SPA corresponding to -170.32 ± 17.55°, -207.56 ± 10.78° and -261.08 ± 10.90°, respectively. Both phantom studies results demonstrated that SPA was highly negative in stiffer arteries. Further, experiments were taken in living healthy rats as control group (n = 3), atherosclerotic model group (n = 3), and drug treated group (n = 3), and the results showed that SPA was most negative in model group, and SPA was least negative in control group. Together, this study suggested that highly negative SPA appeared to be a prominent mechanical feature of vessels prone to atherosclerotic disease.
收录类别	SCI
原文出处	http://iopscience.iop.org/0031-9155/60/11/4281
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7135]
专题	深圳先进技术研究院_医工所
作者单位	PHYSICS IN MEDICINE AND BIOLOGY
推荐引用方式 GB/T 7714	Lili Niu,Long Meng,Lisheng Xu,et al. Stress phase angle depicts differences in arterial stiffness: phantom and in vivo study[J]. PHYSICS IN MEDICINE AND BIOLOGY,2015.
APA	Lili Niu.,Long Meng.,Lisheng Xu.,Jia Liu.,Qiwen Wang.,...&Hairong Zheng.(2015).Stress phase angle depicts differences in arterial stiffness: phantom and in vivo study.PHYSICS IN MEDICINE AND BIOLOGY.
MLA	Lili Niu,et al."Stress phase angle depicts differences in arterial stiffness: phantom and in vivo study".PHYSICS IN MEDICINE AND BIOLOGY (2015).