Hemodynamic characterization of transient blood flow in right coronary arteries with varying curvature and side-branch bifurcation angles | |
Guiying Liu; Jianhuang Wu; Dhanjoo N. Ghist; Wenhua Huang; Kelvin K.L. Wong | |
刊名 | COMPUTERS IN BIOLOGY AND MEDICINE |
2015 | |
英文摘要 | Hemodynamics plays a critical role in the development and progression of plaques that are prone to sites of arterial curvatures and branch bifurcations. The occurrence of atherosclerosis at curvatures of coronary arteries and at the bifurcation sites of their branches are of medical importance. In this study, we have employed computer simulation coupled with a parametric analysis to rigorously quantify the transient wall shear stress (WSS) and wall pressure gradient (WPG) in idealized and image-based right coronary artery (RCA) models with side-branches, in order to explore the effects of curvatureand bifurcation on blood flow characteristics and its hemodynamic variables. Upon establishing and implementing this parametric analysis framework, it is found that the relatively lower wall shear stress and WPG regions at the curvature and branch bifurcation sites of arteries coincide with the plaques prone points of the three investigated image-based arteries, to thereby confirm the correlation of the fluid mechanical properties with the arterial geometry variation in consistence with the data from existing literatures. Moreover, the average WSS and Pressure drop (from inlet to outlet) are significantly increased with the more complex geometry of realistic arteries in comparison with idealized arterial models. It can hence be concluded that the geometry of curvature and angulation of the side branches has a significant effect on the WSS and WPG in hemodynamics analysis of RCAs and its correlation with atherosclerotic lesions. |
收录类别 | SCI |
原文出处 | http://www.sciencedirect.com/science/article/pii/S0010482515002176 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.siat.ac.cn:8080/handle/172644/7094] |
专题 | 深圳先进技术研究院_医工所 |
作者单位 | COMPUTERS IN BIOLOGY AND MEDICINE |
推荐引用方式 GB/T 7714 | Guiying Liu,Jianhuang Wu,Dhanjoo N. Ghist,et al. Hemodynamic characterization of transient blood flow in right coronary arteries with varying curvature and side-branch bifurcation angles[J]. COMPUTERS IN BIOLOGY AND MEDICINE,2015. |
APA | Guiying Liu,Jianhuang Wu,Dhanjoo N. Ghist,Wenhua Huang,&Kelvin K.L. Wong.(2015).Hemodynamic characterization of transient blood flow in right coronary arteries with varying curvature and side-branch bifurcation angles.COMPUTERS IN BIOLOGY AND MEDICINE. |
MLA | Guiying Liu,et al."Hemodynamic characterization of transient blood flow in right coronary arteries with varying curvature and side-branch bifurcation angles".COMPUTERS IN BIOLOGY AND MEDICINE (2015). |
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