Functional combination strategy for prioritization of human miRNA target

	Functional combination strategy for prioritization of human miRNA target
	Jing Li; Yunpeng Zhang; Yingying Wang; Chunlong Zhang; Qiuyu Wang; Xinrui Shi; Chunquan Li; Ruijie Zhang; Xia Li
刊名	GENE
	2014
英文摘要	MicroRNAs (miRNAs) are a class of non-coding RNAs known to play important regulatory roles through targets, which can affect human cell proliferation, differentiation, and metabolism. Overlaps between different miRNA target prediction algorithms (MTPAs) are small, which limit the understanding of miRNA's biological functions. However, the overlaps increase on functional levels, such as Gene Ontology (GO), Protein-Protein Interaction Network (PPIN) and pathways. Here, we performed prioritization on existing predicted target sets for each miRNA by considering all the possible combinations of 7 functional levels. After analyzing the results of both single and multiple functional levels, we found that functional combination strategies including pathways and GO performed better in the prioritization of human miRNA target. The combination which performed best was "Pathway + GO BP + GO MF + GO CC + Target + PPIN". For the prioritized result of this combination, the valid target had top ranking, and our method performed better than the MTPAs after comparison adopting the validated ranking levels. Top genes in ranking lists generated by this strategy were either validated by experiments or share same functions with the corresponding miRNA/its validated genes in disease related biological processes.
收录类别	SCI
原文出处	http://ac.els-cdn.com/S0378111913013401/1-s2.0-S0378111913013401-main.pdf?_tid=0f8d0b80-0c7b-11e5-9ee6-00000aab0f6c&acdnat=1433616018_e6a943607606373fa25facc34ed25ae7
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/5790]
专题	深圳先进技术研究院_医工所
作者单位	GENE
推荐引用方式 GB/T 7714	Jing Li,Yunpeng Zhang,Yingying Wang,et al. Functional combination strategy for prioritization of human miRNA target[J]. GENE,2014.
APA	Jing Li.,Yunpeng Zhang.,Yingying Wang.,Chunlong Zhang.,Qiuyu Wang.,...&Xia Li.(2014).Functional combination strategy for prioritization of human miRNA target.GENE.
MLA	Jing Li,et al."Functional combination strategy for prioritization of human miRNA target".GENE (2014).