Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through ​bFGF

	Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF
	Fan Yang; Yunhui Liu; Jie Tu; Jun Wan; Jie Zhang; Bifeng Wu; Shanping Chen; Jiawei Zhou; Yangling Mu; Liping Wang
刊名	NATURE COMMUNICATIONS
	2014
英文摘要	Astrocytes provide neuroprotective effects against degeneration of dopaminergic (DA) neurons and play a fundamental role in DA differentiation of neural stem cells. Here we show that light illumination of astrocytes expressing engineered channelrhodopsin variant (ChETA) can remarkably enhance the release of basic fibroblast growth factor (bFGF) and significantly promote the DA differentiation of human embryonic stem cells (hESCs) in vitro. Light activation of transplanted astrocytes in the substantia nigra (SN) also upregulates bFGF levels in vivo and promotes the regenerative effects of co-transplanted stem cells. Importantly, upregulation of bFGF levels, by specific light activation of endogenous astrocytes in the SN, enhances the DA differentiation of transplanted stem cells and promotes brain repair in a mouse model of Parkinson's disease (PD). Our study indicates that astrocyte-derived bFGF is required for regulation of DA differentiation of the stem cells and may provide a strategy targeting astrocytes for treatment of PD.
收录类别	SCI
原文出处	http://www.nature.com/ncomms/2014/141217/ncomms6627/pdf/ncomms6627.pdf
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/5770]
专题	深圳先进技术研究院_医工所
作者单位	NATURE COMMUNICATIONS
推荐引用方式 GB/T 7714	Fan Yang,Yunhui Liu,Jie Tu,et al. Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF[J]. NATURE COMMUNICATIONS,2014.
APA	Fan Yang.,Yunhui Liu.,Jie Tu.,Jun Wan.,Jie Zhang.,...&Liping Wang.(2014).Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF.NATURE COMMUNICATIONS.
MLA	Fan Yang,et al."Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF".NATURE COMMUNICATIONS (2014).