Computer-assisted assessment of ultrasound real-time elastography: initial experience in 145 breast lesions

	Computer-assisted assessment of ultrasound real-time elastography: initial experience in 145 breast lesions
	Xue Zhang; Yang Xiao; Jie Zeng; Weibao Qiu; Ming Qian; Congzhi Wang; Rongqin Zheng; Hairong Zheng
刊名	EUROPEAN JOURNAL OF RADIOLOGY
	2014
英文摘要	Purpose: To develop and evaluate a computer-assisted method of quantifying five-point elasticity scoring system based on ultrasound real-time elastography (RTE), for classifying benign and malignant breast lesions, with pathologic results as the reference standard. Materials and methods: Conventional ultrasonography (US) and RTE images of 145 breast lesions (67 malignant, 78 benign) were performed in this study. Each lesion was automatically contoured on the B-mode image by the level set method and mapped on the RTE image. The relative elasticity value of each pixel was reconstructed and classified into hard or soft by the fuzzy c-means clustering method. According to the hardness degree inside lesion and its surrounding tissue, the elasticity score of the RTE image was computed in an automatic way. Visual assessments of the radiologists were used for comparing the diagnostic performance. Histopathologic examination was used as the reference standard. The Student's t test and receiver operating characteristic (ROC) curve analysis were performed for statistical analysis. Results: Considering score 4 or higher as test positive for malignancy, the diagnostic accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 93.8% (136/145), 92.5% (62/67), 94.9% (74/78), 93.9% (62/66), and 93.7% (74/79) for the computer-assisted scheme, and 89.7% (130/145), 85.1% (57/67), 93.6% (73/78), 92.0% (57/62), and 88.0% (73/83) for manual assessment. Area under ROC curve (A(z) value) for the proposed method was higher than the A(z) value for visual assessment (0.96 vs. 0.93). Conclusion: Computer-assisted quantification of classical five-point scoring system can significantly eliminate the interobserver variability and thereby improve the diagnostic confidence of classifying the breast lesions to avoid unnecessary biopsy.
收录类别	SCI
原文出处	http://www.sciencedirect.com/science/article/pii/S0720048X1300507X
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/5756]
专题	深圳先进技术研究院_医工所
作者单位	EUROPEAN JOURNAL OF RADIOLOGY
推荐引用方式 GB/T 7714	Xue Zhang,Yang Xiao,Jie Zeng,et al. Computer-assisted assessment of ultrasound real-time elastography: initial experience in 145 breast lesions[J]. EUROPEAN JOURNAL OF RADIOLOGY,2014.
APA	Xue Zhang.,Yang Xiao.,Jie Zeng.,Weibao Qiu.,Ming Qian.,...&Hairong Zheng.(2014).Computer-assisted assessment of ultrasound real-time elastography: initial experience in 145 breast lesions.EUROPEAN JOURNAL OF RADIOLOGY.
MLA	Xue Zhang,et al."Computer-assisted assessment of ultrasound real-time elastography: initial experience in 145 breast lesions".EUROPEAN JOURNAL OF RADIOLOGY (2014).